Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 11/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.32 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | AKT2 | P31751 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1745964 | 0.80 | PDE4A (0.48) | MKNK1PDE4ADYRK1APDE10AAHR | |
| SCHEMBL22189751 | 0.76 | AKT1 (0.48) | PDE4ARIPK3PDE4BPDE4CPDE4D | |
| SCHEMBL1746576 | 0.74 | MKNK1 (0.49) | MKNK1PDE4ARIPK3PDE4BPDE4C | |
| SCHEMBL2068562 | 0.73 | PDE4B (0.35) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2066630 | 0.73 | CA1 (0.36) | MKNK1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3948112 | 0.73 | RIPK3 (0.34) | MKNK1PDE4ARIPK3AKT1AKT2 | |
| SCHEMBL3948108 | 0.72 | ALOX5 (0.36) | PDE4ARIPK3PDE4BPDE4CPDE4D | |
| SCHEMBL17492375 | 0.68 | PDE4B (0.62) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL477032 | 0.67 | MKNK1 (0.53) | MKNK1PDE4ADYRK1APDE4BPDE4D | |
| SCHEMBL10437261 | 0.67 | PDE10A (0.41) | MKNK1PDE4APDE10APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3007698-A1 | COMBINATION OF A IMIDAZOPYRIDAZINE DERIVATIVE AND A MITOTIC AGENT FOR THE TREATMENT OF CANCER | Bayer Pharma Aktiengesellschaft (DE) | 2016-04-20 | — | — | EP | disclosed |
| WO-2014198776-A1 | COMBINATION OF A IMIDAZOPYRIDAZINE DERIVATIVE AND A MITOTIC AGENT FOR THE TREATMENT OF CANCER | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-12-18 | — | — | WO | disclosed |
| WO-2014020041-A1 | COMBINATIONS FOR THE TREATMENT OF CANCER | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-02-06 | — | — | WO | disclosed |
| EP-2614063-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | Bayer Intellectual Property GmbH (DE) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012032031-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-15 | — | — | WO | disclosed |