SCHEMBL1746735

SCHEMBL1746735

CC(C)(C)OC(=O)N1CCC[C@H]1c1ncc(-c2cccc(-c3cccc(-c4c[nH]c([C@@]5(C(C)(C)C)CCCN5C(=O)O)n4)c3)c2)[nH]1

nearest known ligand 0.44

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PRCP P42785 10/20 0.44
HPGDS O60760 3/20 0.42
HCRTR1 O43613 3/20 0.39
HCRTR2 O43614 3/20 0.39
OPRM1 P35372 2/20 0.38
OPRD1 P41143 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1746313 0.88 CYP3A4 (0.39) PRCPHPGDSHCRTR1HCRTR2
SCHEMBL1745859 0.87 PRCP (0.41) PRCPHPGDSHCRTR1HCRTR2
SCHEMBL1817518 0.85 HPGDS (0.35) PRCPHPGDSOPRM1OPRD1
SCHEMBL3350952 0.84 PRCP (0.51) PRCPHPGDSHCRTR1HCRTR2
SCHEMBL1746732 0.84 PRCP (0.51) PRCPHPGDSHCRTR1HCRTR2
SCHEMBL12158439 0.82 PRCP (0.58) PRCPHPGDSHCRTR1HCRTR2
SCHEMBL15424223 0.82 PRCP (0.58) PRCPHPGDSHCRTR1HCRTR2
SCHEMBL883084 0.82 PRCP (0.58) PRCPHPGDSHCRTR1HCRTR2
SCHEMBL21813194 0.82 PRCP (0.41) PRCPHPGDSHCRTR1HCRTR2OPRM1
SCHEMBL21813196 0.82 PRCP (0.41) PRCPHPGDSHCRTR1HCRTR2OPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2049522-B1 HEPATITIS C VIRUS INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2014-05-14 EP claimed
EP-2385048-A1 Hepatitis C virus inhibitors Bristol-Myers Squibb Company (US) 2011-11-09 EP disclosed
US-20110268697-A1 Hepatitis C Virus Inhibitors BRISTOL-MYERS SQUIBB COMPANY 2011-11-03 US disclosed
US-20110252687-A1 Canting Vertical Fore Grip with Bipod GRIP POD SYSTEMS, LLC 2011-10-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110268697-A1 Hepatitis C Virus Inhibitors HAVCR2, PYGL, HCCS PRCP 190/4885HPGDS 582/4885HCRTR1 4453/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.