Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23260541 | 0.84 | PARP1 (0.47) | PARP1HDAC8HDAC6SMN1; SMN2HPGD | |
| SCHEMBL23320218 | 0.78 | PARP1 (0.37) | PARP1HDAC8HDAC6SMN1; SMN2HPGD | |
| SCHEMBL17034487 | 0.78 | PARP1 (0.42) | PARP1HDAC8HDAC6SMN1; SMN2HPGD | |
| SCHEMBL24711679 | 0.77 | PARP1 (0.48) | PARP1HDAC8HDAC6SMN1; SMN2HPGD | |
| SCHEMBL20037381 | 0.75 | HDAC8 (0.43) | PARP1HDAC8HDAC6SMN1; SMN2HPGD | |
| SCHEMBL23319685 | 0.71 | KDM4E (0.34) | PARP1HDAC8HDAC6HPGDTDP1 | |
| SCHEMBL15471903 | 0.71 | PARP1 (0.46) | PARP1HDAC8HDAC6SMN1; SMN2HPGD | |
| SCHEMBL11787750 | 0.70 | PARP1 (0.52) | PARP1HDAC8HDAC6SMN1; SMN2HPGD | |
| SCHEMBL11787753 | 0.70 | PARP1 (0.52) | PARP1HDAC8HDAC6SMN1; SMN2HPGD | |
| SCHEMBL15472207 | 0.70 | PARP1 (0.41) | PARP1HDAC8HDAC6SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9464096-B2 | Therapeutic compounds | GILEAD SCIENCES, INC. (US) | 2016-10-11 | — | — | US | disclosed |
| US-20160024104-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. | 2016-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160024104-A1 | THERAPEUTIC COMPOUNDS | NFATC1, FURIN, NPC1 | PARP1 3070/4885HDAC8 1774/4885HDAC6 284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.