Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.31 |
| ▸ | WNT3A | P56704 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17468521 | 0.78 | PARP1 (0.41) | PARP1HDAC8HDAC6SMN1; SMN2TDP1 | |
| SCHEMBL23260541 | 0.76 | PARP1 (0.47) | PARP1HDAC8HDAC6SMN1; SMN2TDP1 | |
| SCHEMBL23319685 | 0.75 | KDM4E (0.34) | PARP1HDAC8HDAC6TDP1HPGD | |
| SCHEMBL17034487 | 0.73 | PARP1 (0.42) | PARP1HDAC8HDAC6SMN1; SMN2TDP1 | |
| SCHEMBL24711679 | 0.73 | PARP1 (0.48) | PARP1HDAC8HDAC6SMN1; SMN2TDP1 | |
| SCHEMBL24711143 | 0.72 | PARP1 (0.47) | PARP1HDAC8HDAC6SMN1; SMN2TDP1 | |
| SCHEMBL20037381 | 0.70 | HDAC8 (0.43) | PARP1HDAC8HDAC6SMN1; SMN2TDP1 | |
| SCHEMBL610252 | 0.67 | PARP1 (0.54) | PARP1HDAC8HDAC6SMN1; SMN2TDP1 | |
| SCHEMBL29444189 | 0.67 | PARP1 (0.54) | PARP1HDAC8HDAC6SMN1; SMN2TDP1 | |
| SCHEMBL15471903 | 0.67 | PARP1 (0.46) | PARP1HDAC8HDAC6SMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021087144-A1 | THERAPEUTIC METHODS USING VADADUSTAT | AKEBIA THERAPEUTICS, INC. (US) | 2021-05-06 | — | — | WO | disclosed |