Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23320218 | 0.75 | PARP1 (0.37) | MAPTALDH1A1TDP1HPGDTP53 | |
| SCHEMBL17468521 | 0.71 | PARP1 (0.41) | MAPTALDH1A1TDP1HPGDPARP1 | |
| SCHEMBL23260541 | 0.69 | PARP1 (0.47) | MAPTALDH1A1TDP1HPGDTP53 | |
| SCHEMBL17034487 | 0.67 | PARP1 (0.42) | MAPTALDH1A1TDP1HPGDPARP1 | |
| SCHEMBL24711679 | 0.66 | PARP1 (0.48) | TDP1HPGDPARP1RAB9AHDAC8 | |
| SCHEMBL5309099 | 0.65 | TDP1 (0.53) | KDM4EMAPTALDH1A1HTTTDP1 | |
| SCHEMBL20037381 | 0.64 | HDAC8 (0.43) | MAPTALDH1A1TDP1HPGDTP53 | |
| SCHEMBL16952628 | 0.64 | TDP1 (0.52) | MAPTALDH1A1TDP1HPGDTP53 | |
| SCHEMBL22808116 | 0.64 | TDP1 (0.41) | MAPTALDH1A1TDP1HPGDTP53 | |
| SCHEMBL19959693 | 0.64 | SMN1; SMN2 (0.45) | MAPTALDH1A1TDP1TP53ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021087144-A1 | THERAPEUTIC METHODS USING VADADUSTAT | AKEBIA THERAPEUTICS, INC. (US) | 2021-05-06 | — | — | WO | disclosed |