SCHEMBL17469413

SCHEMBL17469413

CCOC(=O)c1c(C)cc(-c2ccccc2)cc1-c1ccc(F)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.54
KDM4E B2RXH2 6/20 0.54
GAA P10253 5/20 0.54
HPGD P15428 4/20 0.54
MEN1 O00255 2/20 0.54
KMT2A Q03164 2/20 0.54
PRKCZ Q05513 1/20 0.52
PTPN1 P18031 2/20 0.51
MAPT P10636 3/20 0.49
TP53 P04637 1/20 0.47
SMN1; SMN2 Q16637 4/20 0.46
LMNA P02545 2/20 0.46
GRM6 O15303 1/20 0.46
CYP1A2 P05177 1/20 0.46
CYP3A4 P08684 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C9 P11712 1/20 0.46
CYP2C19 P33261 1/20 0.46
RAB9A P51151 4/20 0.46
NPC1 O15118 3/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17459519 0.87 SLC6A4 (0.54) ALDH1A1KDM4EHPGDMEN1KMT2A
SCHEMBL9857473 0.84 DHODH (0.48) KDM4EMEN1KMT2APTPN1MAPT
SCHEMBL30189523 0.79 ALDH1A1 (0.57) ALDH1A1KDM4EGAAHPGDMEN1
SCHEMBL11671418 0.79 ALDH1A1 (0.48) ALDH1A1KDM4EGAAHPGDMEN1
SCHEMBL22730883 0.78 ALDH1A1 (0.60) ALDH1A1KDM4EGAAHPGDMEN1
SCHEMBL17459525 0.78 HTT (0.55) ALDH1A1KDM4EHPGDMEN1KMT2A
SCHEMBL10429239 0.76 ALDH1A1 (0.54) ALDH1A1KDM4EGAAHPGDMEN1
SCHEMBL9857871 0.76 DHODH (0.50) MEN1KMT2APTPN1RAB9APTPN2
SCHEMBL17459507 0.76 HTT (0.50) ALDH1A1KDM4EHPGDMEN1KMT2A
SCHEMBL27636759 0.75 ALDH1A1 (0.55) ALDH1A1KDM4EGAAHPGDMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016013976-A1 METHOD OF FORMING A MULTI-SUBSTITUTED BENZENE COMPOUND NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2016-01-28 WO disclosed