Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 12/20 | 0.69 |
| ▸ | ESR1 | P03372 | 11/20 | 0.69 |
| ▸ | ESR2 | Q92731 | 9/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.63 |
| ▸ | EBP | Q15125 | 2/20 | 0.63 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.63 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.63 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.63 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.63 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.63 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.63 |
| ▸ | DRD3 | P35462 | 2/20 | 0.63 |
| ▸ | HTR6 | P50406 | 2/20 | 0.63 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | IDH1 | O75874 | 1/20 | 0.63 |
| ▸ | EGFR | P00533 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17152214 | 0.94 | CYP19A1 (0.81) | CYP19A1ESR1ESR2CYP3A4KCNH2 | |
| SCHEMBL8639618 | 0.84 | ESR1 (0.63) | CYP19A1ESR1ESR2CYP3A4KCNH2 | |
| SCHEMBL8613926 | 0.84 | ESR1 (0.63) | CYP19A1ESR1ESR2CYP3A4KCNH2 | |
| SCHEMBL8639615 | 0.84 | ESR1 (0.63) | CYP19A1ESR1ESR2CYP3A4KCNH2 | |
| SCHEMBL17790416 | 0.84 | ESR1 (0.72) | CYP19A1ESR1ESR2CYP3A4KCNH2 | |
| SCHEMBL17790415 | 0.84 | ESR1 (0.72) | CYP19A1ESR1ESR2CYP3A4KCNH2 | |
| SCHEMBL8639612 | 0.84 | ESR1 (0.63) | CYP19A1ESR1ESR2CYP3A4KCNH2 | |
| SCHEMBL8644016 | 0.83 | ESR1 (0.62) | CYP19A1ESR1ESR2KCNH2EBP | |
| SCHEMBL8644014 | 0.83 | ESR1 (0.62) | CYP19A1ESR1ESR2KCNH2EBP | |
| SCHEMBL8644018 | 0.83 | ESR1 (0.62) | CYP19A1ESR1ESR2KCNH2EBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016014812-A1 | TREATING ANDROGEN DEPRIVATION THERAPY INDUCED HOT FLASHES AND BONE LOSS USING CIS-CLOMIPHENE | ASPEN PARK PHARMACEUTICALS, INC. (US) | 2016-01-28 | — | — | WO | disclosed |