Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | FNTA | P49354 | 1/20 | 0.43 |
| ▸ | FNTB | P49356 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2077595 | 0.84 | PKM (0.53) | PKMFNTAFNTBKDM4EKMT2A | |
| SCHEMBL174800 | 0.84 | PKM (0.53) | PKMFNTAFNTBKDM4EKMT2A | |
| SCHEMBL12629482 | 0.84 | PKM (0.53) | PKMFNTAFNTBKDM4EKMT2A | |
| SCHEMBL4760141 | 0.81 | PKM (0.50) | PKMFNTAFNTBKDM4EKMT2A | |
| Hydrochloric Acid SCHEMBL1743177 | 0.80 | PKM (0.44) | PKMFNTAFNTBKDM4EKDR | |
| SCHEMBL2073708 | 0.80 | PKM (0.49) | PKMFNTAFNTBKDM4EKMT2A | |
| SCHEMBL4758003 | 0.80 | PKM (0.49) | PKMFNTAFNTBKDM4EKMT2A | |
| SCHEMBL2075577 | 0.80 | PKM (0.49) | PKMFNTAFNTBKDM4EKMT2A | |
| SCHEMBL2193196 | 0.79 | PKM (0.55) | PKMFNTAFNTBKDM4EKMT2A | |
| SCHEMBL8234335 | 0.79 | PKM (0.55) | PKMFNTAFNTBKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130303533-A1 | AZOLOPYRIDINE AND AZOLOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2013-11-14 | — | — | US | disclosed |
| EP-2611809-A1 | AZOLOPYRIDINE AND AZOLOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030924-A1 | AZOLOPYRIDINE AND AZOLOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2012-03-08 | — | — | WO | disclosed |
| EP-0178759-B1 | ALKYNYL DERIVATIVESOF PYRAZOLO-(3,4-B)-PYRIDINE LACTAMS | ICI AMERICAS INC. (US) | 1990-01-10 | — | — | EP | disclosed |
| US-4705793-A | Pyrazolo[3,4-b]pyrrolo[3,4-e]pyridine-5(1H)-one and 1-H-pyrazolo[3,4-b][1,6]naphthyridine-5(6H)-one derivations, useful as anti-anxiety agents | ICI AMERICAS INC. (US) | 1987-11-10 | — | — | US | disclosed |
| EP-0178759-A1 | Alkynyl derivativesof pyrazolo-(3,4-b)-pyridine lactams | ICI AMERICAS INC. (US) | 1986-04-23 | — | — | EP | disclosed |
| US-4546104-A | Pyrazolopyridine cycloalkanones and process for their preparation | ICI AMERICAS INC. (US) | 1985-10-08 | — | — | US | disclosed |
| EP-0141608-A2 | Pyrazolopyridine cycloalkanone derivatives | ICI AMERICAS INC. (US) | 1985-05-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130303533-A1 | AZOLOPYRIDINE AND AZOLOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | JAK3, JAK2, JAK1 | PKM 534/4885FNTA 4635/4885FNTB 4570/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.