Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.39 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1741752 | 0.98 | PKM (0.48) | PKMKDM4EKMT2AGAAHSD17B10 | |
| SCHEMBL11899586 | 0.98 | PKM (0.48) | PKMKDM4EKMT2AGAAHSD17B10 | |
| SCHEMBL1742738 | 0.98 | PKM (0.48) | PKMKDM4EKMT2AGAAHSD17B10 | |
| SCHEMBL1740693 | 0.98 | PKM (0.48) | PKMKDM4EKMT2AGAAHSD17B10 | |
| SCHEMBL4760141 | 0.95 | PKM (0.50) | PKMKDM4EKMT2AGAAHSD17B10 | |
| SCHEMBL2077595 | 0.88 | PKM (0.53) | PKMKDM4EKMT2AMEN1FNTA | |
| SCHEMBL4338327 | 0.87 | KDR (0.40) | PKMKDM4EKMT2AGAAHSD17B10 | |
| SCHEMBL2193196 | 0.81 | PKM (0.55) | PKMKDM4EKMT2AMEN1FNTA | |
| SCHEMBL174714 | 0.80 | PKM (0.54) | PKMKDM4EKMT2AMEN1FNTA | |
| SCHEMBL2077800 | 0.78 | PKM (0.50) | PKMKDM4EKMT2AHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0282811-A1 | 4-Cyano-1-aryl-pyrazoles | BAYER AG (DE) | 1988-09-21 | — | — | EP | claimed |
| EP-2024360-B1 | SUBSTITUTED PYRAZOLOPYRIMIDINES | CEPHALON INC (US) | 2013-04-03 | — | — | EP | disclosed |
| US-8354414-B2 | Substituted bicyclic pyrimidines | CEPHALON, INC (US) | 2013-01-15 | — | — | US | disclosed |
| US-8354414-B2 | Substituted bicyclic pyrimidines | CEPHALON, INC (US) | 2013-01-15 | — | — | US | disclosed |
| US-8354414-B2 | Substituted bicyclic pyrimidines | CEPHALON, INC (US) | 2013-01-15 | — | — | US | disclosed |
| EP-2351751-A1 | Substituted pyrazolopyrimidines | CEPHALON, INC. (US) | 2011-08-03 | — | — | EP | disclosed |
| US-20110053920-A1 | SUBSTITUTED BICYCLIC PYRIMIDINES | CEPHALON, INC. (US) | 2011-03-03 | — | — | US | disclosed |
| US-20110053920-A1 | SUBSTITUTED BICYCLIC PYRIMIDINES | CEPHALON, INC. (US) | 2011-03-03 | — | — | US | disclosed |
| US-20110053920-A1 | SUBSTITUTED BICYCLIC PYRIMIDINES | CEPHALON, INC. (US) | 2011-03-03 | — | — | US | disclosed |
| US-7851468-B2 | Substituted pyrazolo[3,4-d]pyrimidines | CEPHALON, INC. (US) | 2010-12-14 | — | — | US | disclosed |
| US-4804398-A | 1-aryl-4-cyano-5-halogenopyrazoles, composition containing them, and method of using them as selective herbicides | BAYER AKTIENGESELLSCHAFT (DE) | 1989-02-14 | — | — | US | disclosed |
| EP-0282811-A1 | 4-Cyano-1-aryl-pyrazoles | BAYER AG (DE) | 1988-09-21 | — | — | EP | disclosed |
| US-4747867-A | 1-aryl-4-cyano-5-halogenopyrazoles, composition containing them, and herbicidal method of using them | BAYER AKTIENGESELLSCHAFT (DE) | 1988-05-31 | — | — | US | disclosed |
| US-4645838-A | Pyrazolopyridine compounds, and intermediates, useful as anxiolytic agents | ICI AMERICAS INC. (US) | 1987-02-24 | — | — | US | disclosed |
| EP-0094175-B1 | PYRAZOLOPYRIDINE COMPOUNDS | ICI AMERICAS INC. (US) | 1986-10-29 | — | — | EP | disclosed |
| US-4563525-A | Process for preparing pyrazolopyridine compounds | ICI AMERICAS INC. (US) | 1986-01-07 | — | — | US | disclosed |
| US-4546104-A | Pyrazolopyridine cycloalkanones and process for their preparation | ICI AMERICAS INC. (US) | 1985-10-08 | — | — | US | disclosed |
| EP-0141608-A2 | Pyrazolopyridine cycloalkanone derivatives | ICI AMERICAS INC. (US) | 1985-05-15 | — | — | EP | disclosed |
| US-4511568-A | CNS-Depressant pyrazolopyridines | ICI AMERICAS INC. (US) | 1985-04-16 | — | — | US | disclosed |
| EP-0094175-A1 | Pyrazolopyridine compounds | ICI AMERICAS INC. (US) | 1983-11-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053920-A1 | SUBSTITUTED BICYCLIC PYRIMIDINES | DPYD, P2RX5, P2RX7 | PKM 1134/4885KDM4E 3148/4885KMT2A 3404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.