Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 20/20 | 0.82 |
| ▸ | HSP90AA1 | P07900 | 19/20 | 0.82 |
| ▸ | HSP90B1 | P14625 | 3/20 | 0.71 |
| ▸ | TRAP1 | Q12931 | 3/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1746133 | 1.00 | HSP90AB1 (0.82) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL1220259 | 0.97 | HSP90AB1 (0.88) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL1220250 | 0.97 | HSP90AB1 (0.88) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL1747239 | 0.92 | HSP90AB1 (0.73) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL1746135 | 0.92 | HSP90AB1 (0.73) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL1220721 | 0.91 | HSP90AB1 (0.85) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL1220714 | 0.91 | HSP90AB1 (0.85) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL1221151 | 0.90 | HSP90AA1 (1.00) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL3632430 | 0.90 | HSP90AB1 (0.88) | HSP90AB1HSP90AA1HSP90B1TRAP1 | |
| SCHEMBL1221155 | 0.90 | HSP90AA1 (1.00) | HSP90AB1HSP90AA1HSP90B1TRAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2380879-B1 | Tetrahydroindolone and tetrahydroindazolone derivatives | ESANEX INC (US) | 2017-07-12 | — | — | EP | disclosed |
| EP-1856057-B1 | TETRAHYDROINDOLONE AND TETRAHYDROINDAZOLONE DERIVATIVES | SERENEX INC (US) | 2014-10-15 | — | — | EP | disclosed |
| EP-2380879-A1 | Tetrahydroindolone and tetrahydroindazolone derivatives | Serenex, Inc. (US) | 2011-10-26 | — | — | EP | disclosed |
| US-20110252835-A1 | HEAT PUMP (SERVER) COUPLED WASHER AND DRYER PAIR | WHIRLPOOL CORPORATION (US) | 2011-10-20 | — | — | US | disclosed |