SCHEMBL1747385

SCHEMBL1747385

O=C(O)CCc1ccc(OCc2ccc(CNCc3cccc(Oc4ccccc4)c3)cc2)cc1

nearest known ligand 0.80

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 18/20 0.80
FFAR4 Q5NUL3 7/20 0.80
GNA15 P30679 1/20 0.66
PTGER3 P43115 1/20 0.66
TDP1 Q9NUW8 1/20 0.66
BCHE P06276 1/20 0.60
AKR1B1 P15121 1/20 0.60
KDM4E B2RXH2 1/20 0.57
ALDH1A1 P00352 1/20 0.57
HTT P42858 1/20 0.57
SMN1; SMN2 Q16637 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1745299 0.93 FFAR1 (0.84) FFAR1FFAR4TDP1BCHEAKR1B1
SCHEMBL1745467 0.89 FFAR1 (1.00) FFAR1FFAR4GNA15PTGER3TDP1
SCHEMBL1747342 0.87 FFAR1 (0.80) FFAR1FFAR4PTGER3AKR1B1
SCHEMBL15890861 0.86 FFAR1 (0.72) FFAR1FFAR4GNA15PTGER3TDP1
SCHEMBL1747130 0.85 FFAR1 (1.00) FFAR1FFAR4AKR1B1
SCHEMBL1744943 0.85 FFAR1 (1.00) FFAR1FFAR4AKR1B1
SCHEMBL1747433 0.85 FFAR1 (0.94) FFAR1FFAR4TDP1AKR1B1
SCHEMBL1744653 0.84 FFAR1 (1.00) FFAR1FFAR4AKR1B1
SCHEMBL13686585 0.83 BCHE (0.79) FFAR1FFAR4BCHEAKR1B1
SCHEMBL1746714 0.83 FFAR1 (0.84) FFAR1FFAR4PTGER3TDP1BCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1559422-B1 RECEPTOR FUNCTION CONTROLLING AGENT TAKEDA PHARMACEUTICAL (JP) 2014-04-30 EP disclosed
EP-2385032-A1 GPR40 Receptor function regulator Takeda Pharmaceutical Company Limited (JP) 2011-11-09 EP disclosed
EP-2385032-A1 GPR40 Receptor function regulator Takeda Pharmaceutical Company Limited (JP) 2011-11-09 EP disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
EP-1559422-A1 RECEPTOR FUNCTION CONTROLLING AGENT Takeda Pharmaceutical Company Limited (JP) 2005-08-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090012093-A1 Receptor Function Regulator GPR119, GIPR, INSR FFAR1 33/4885FFAR4 44/4885GNA15 1001/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.