Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 9/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | WDR5 | P61964 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | WNK1 | Q9H4A3 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8446562 | 0.88 | PDE4B (0.41) | PDE4BALDH1A1MAPTADORA3ADORA2B | |
| SCHEMBL1746373 | 0.88 | PDE4B (0.39) | PDE4BALDH1A1ADORA3ADORA2BADORA1 | |
| SCHEMBL1746227 | 0.83 | PDE4B (0.43) | PDE4BALDH1A1MAPTADORA3ADORA2B | |
| SCHEMBL1746476 | 0.81 | AKT1 (0.37) | PDE4BALDH1A1MAPK1LMNA | |
| SCHEMBL1746301 | 0.81 | KDM4E (0.41) | PDE4BALDH1A1MAPTADORA3ADORA1 | |
| SCHEMBL8443924 | 0.77 | BUB1 (0.44) | PDE4BADORA1ADORA2A | |
| SCHEMBL8442660 | 0.76 | USP30 (0.39) | PDE4BMEN1KMT2A | |
| SCHEMBL8442707 | 0.73 | PDE4B (0.41) | PDE4BALDH1A1MAPTADORA3ADORA2B | |
| SCHEMBL8442662 | 0.71 | BUB1 (0.37) | PDE4BALDH1A1HTT | |
| SCHEMBL1746587 | 0.70 | PDE4B (0.39) | PDE4BALDH1A1ADORA3ADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2380890-A1 | New 7,8-dihydro-1,6-naphthyridin-5(6h)-one-derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2011-10-26 | — | — | EP | disclosed |
| US-20110253549-A1 | WASHING APPARATUS AND METHOD OF DEODORIZING WASHING WATER | KANNO MINORU | 2011-10-20 | — | — | US | disclosed |