Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.31 |
| ▸ | IDH2 | P48735 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17476832 | 1.00 | ACHE (0.33) | ACHEIDH1IDH2TTK | |
| SCHEMBL17476829 | 1.00 | ACHE (0.33) | ACHEIDH1IDH2TTK | |
| SCHEMBL21995617 | 0.78 | ACHE (0.33) | ACHETTK | |
| SCHEMBL21995619 | 0.78 | ACHE (0.33) | ACHETTK | |
| SCHEMBL21995811 | 0.78 | ACHE (0.33) | ACHETTK | |
| SCHEMBL29475912 | 0.78 | ACHE (0.33) | ACHETTK | |
| SCHEMBL21979470 | 0.76 | — | — | |
| SCHEMBL1365662 | 0.76 | — | — | |
| SCHEMBL17476836 | 0.75 | JAK2 (0.36) | ACHEIDH1IDH2 | |
| SCHEMBL17476841 | 0.75 | JAK2 (0.36) | ACHEIDH1IDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9688680-B2 | Compositions useful for treating disorders related to kit | BLUEPRINT MEDICINES CORPORATION (US) | 2017-06-27 | — | — | US | disclosed |
| US-9688680-B2 | Compositions useful for treating disorders related to kit | BLUEPRINT MEDICINES CORPORATION (US) | 2017-06-27 | — | — | US | disclosed |
| US-9688680-B2 | Compositions useful for treating disorders related to kit | BLUEPRINT MEDICINES CORPORATION (US) | 2017-06-27 | — | — | US | disclosed |
| WO-2016022569-A1 | COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO KIT | BLUEPRINT MEDICINES CORPORATION (US) | 2016-02-11 | — | — | WO | disclosed |
| WO-2016022569-A1 | COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO KIT | BLUEPRINT MEDICINES CORPORATION (US) | 2016-02-11 | — | — | WO | disclosed |
| US-20160031892-A1 | COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO KIT | BLUEPRINT MEDICINES CORPORATION | 2016-02-04 | — | — | US | disclosed |
| US-20160031892-A1 | COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO KIT | BLUEPRINT MEDICINES CORPORATION | 2016-02-04 | — | — | US | disclosed |
| US-20160031892-A1 | COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO KIT | BLUEPRINT MEDICINES CORPORATION | 2016-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160031892-A1 | COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO KIT | KIT, APC, CKMT1A; CKMT1B | ACHE 1484/4885IDH1 937/4885IDH2 1574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.