Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Zolpidem. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 4/20 | 0.85 |
| ▸ | GABRB1 known ✓ | P18505 | 1/20 | 0.85 |
| ▸ | GABRG2 known ✓ | P18507 | 1/20 | 0.85 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.85 |
| ▸ | ALB | P02768 | 2/20 | 0.85 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.85 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.85 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.85 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.85 |
| ▸ | LMNA | P02545 | 1/20 | 0.85 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.85 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.85 |
| ▸ | HPGD | P15428 | 1/20 | 0.85 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.85 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.85 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.85 |
| ▸ | HTR2B | P41595 | 1/20 | 0.85 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.85 |
| ▸ | TSPO | P30536 | 2/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zolpidem SCHEMBL17004049 | 1.00 | GABRB2 (0.85) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL8207467 | 1.00 | GABRB2 (0.85) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL40721 | 1.00 | GABRB2 (0.85) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL1402195 | 1.00 | GABRB2 (0.85) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL29382172 | 1.00 | GABRB2 (0.85) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL30604720 | 1.00 | GABRB2 (0.85) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL7127421 | 1.00 | GABRB2 (0.85) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL7575406 | 0.99 | GABRB2 (0.83) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL876109 | 0.99 | GABRB2 (0.83) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL22685033 | 0.99 | GABRB2 (0.83) | GABRB2GABRA1ALBOPRK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 1074588 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018087368-A1 | DEVICE FOR REMOVING ORGANS FROM A HUMAN OR ANIMAL BODY | Büscherhoff, Bernd (DE) | 2018-05-17 | — | — | WO | claimed |
| EP-3170513-B1 | DECONTAMINATION ASSEMBLY WITH ADJUSTABLE CATALYST AND METHOD OF OPERATION | METALL PLASTIC GMBH (DE) | 2018-04-25 | — | — | EP | claimed |
| EP-3312473-A1 | BALL SCREW AND METHOD FOR COMPENSATING THE IMBALANCE OF SAME | SFS Intec Holding AG (CH) | 2018-04-25 | — | — | EP | claimed |
| EP-3310623-A1 | CONNECTING OPERATING STATES OF A MOTOR VEHICLE AND A VEHICLE-EXTERNAL DEVICE | Audi AG (DE) | 2018-04-25 | — | — | EP | claimed |
| EP-3080356-B1 | RAIL VEHICLE COMPRISING SNOW PLOUGH | SIEMENS AG (DE) | 2018-04-25 | — | — | EP | claimed |
| EP-3310704-A1 | OVERLOAD PROTECTION MEANS FOR A HOIST AND HOIST HAVING SAME | Konecranes Global Corporation (FI) | 2018-04-25 | — | — | EP | claimed |
| EP-2441532-B1 | NICKEL-PLATED STEEL SHEET AND PROCESS FOR PRODUCING BATTERY CAN USING THE NICKEL-PLATED STEEL SHEET | TOYO KOHAN CO LTD (JP) | 2018-04-04 | — | — | EP | claimed |
| EP-2804213-B1 | Semiconductor power module and assembly with the same | SEMIKRON ELEKTRONIK GMBH & CO KG (DE) | 2018-04-04 | — | — | EP | claimed |
| EP-2624260-B1 | Forward converter with magnetic component | DET INT HOLDING LTD (KY) | 2018-04-04 | — | — | EP | claimed |
| US-20180078534-A1 | COMPOSITIONS AND METHODS FOR TREATING MIDDLE-OF-THE-NIGHT INSOMNIA | PARATEK PHARMACEUTICALS, INC. (US) | 2018-03-22 | — | — | US | claimed |
| EP-0000883-B1 | INSULATED GATE FIELD EFFECT TRANSISTOR | International Business Machines Corporation (US) | 1980-05-28 | — | — | EP | claimed |
| WO-1980000680-A1 | SECURITY REARVIEW MIRROR C | BOSCH MONTI V D (CH) | 1980-04-17 | — | — | WO | claimed |
| WO-1980000675-A1 | METHOD OF PREPARATION,WITH MACHINE AIDS,F SHOES WITH COMPLE TELY COATED SOLES | BATA SCHUHE AG (CH) | 1980-04-17 | — | — | WO | claimed |
| WO-1980000408-A1 | MAKING AND USE OF A COMBINED DENTAL SCREW | DUSCIO H | 1980-03-20 | — | — | WO | claimed |
| WO-1980000269-A1 | ASSEMBLY OF CONTROL VALVES FOR PNEUMATIC CONTROL AT LOW PRESSURE AND WORKING PRESSURE | WIRZ E (CH) | 1980-02-21 | — | — | WO | claimed |
| EP-0005412-A2 | Cross beam for construction of crib walls | Gysi, Hansjürg (CH) | 1979-11-14 | — | — | EP | claimed |
| EP-0004677-A1 | Device for the sealing and shutting of fire-proof closures | GTE Gesellschaft für Technische Entwicklung AG (CH) | 1979-10-17 | — | — | EP | claimed |
| EP-0002796-A1 | Sheet or web feeding device for a printing apparatus | International Business Machines Corporation (US) | 1979-07-11 | — | — | EP | claimed |
| EP-0001757-A1 | Coaxial electric switch | Heist, Ernst, Dipl.-Phys. (DE) | 1979-05-16 | — | — | EP | claimed |
| EP-0001551-A1 | X-ray film cassette with emptying means | Agfa-Gevaert AG (DE) | 1979-05-02 | — | — | EP | claimed |