Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Zolpidem. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 4/20 | 0.85 |
| ▸ | GABRB1 known ✓ | P18505 | 1/20 | 0.85 |
| ▸ | GABRG2 known ✓ | P18507 | 1/20 | 0.85 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.85 |
| ▸ | ALB | P02768 | 2/20 | 0.85 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.85 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.85 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.85 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.85 |
| ▸ | LMNA | P02545 | 1/20 | 0.85 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.85 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.85 |
| ▸ | HPGD | P15428 | 1/20 | 0.85 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.85 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.85 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.85 |
| ▸ | HTR2B | P41595 | 1/20 | 0.85 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.85 |
| ▸ | TSPO | P30536 | 2/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zolpidem SCHEMBL17004049 | 1.00 | GABRB2 (0.85) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL8207467 | 1.00 | GABRB2 (0.85) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL40721 | 1.00 | GABRB2 (0.85) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL29382172 | 1.00 | GABRB2 (0.85) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL30604720 | 1.00 | GABRB2 (0.85) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL7127421 | 1.00 | GABRB2 (0.85) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL17477 | 1.00 | GABRB2 (0.85) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL7575406 | 0.99 | GABRB2 (0.83) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL876109 | 0.99 | GABRB2 (0.83) | GABRB2GABRA1ALBOPRK1KCNH2 | |
| Zolpidem SCHEMBL22685033 | 0.99 | GABRB2 (0.83) | GABRB2GABRA1ALBOPRK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014063820-A1 | VIBRATION-REDUCING DEVICE FOR HOUSINGS | BARKAM GERWIN (DE) | 2014-05-01 | — | — | WO | claimed |
| EP-2549128-A1 | Functional element with anti-twist properties and assembly component comprising the functional element and a sheet metal section | Profil Verbindungstechnik GmbH & Co. KG (DE) | 2013-01-23 | — | — | EP | claimed |
| EP-4239327-A1 | BIOFILM SENSOR AND METHOD FOR BIOFILM DETECTION | Schellbach, Winfried (DE) | 2023-09-06 | — | — | EP | disclosed |
| EP-4168813-A1 | DETERMINATION OF A STATE OF HEALTH OF AN ENERGY STORE | TWAICE Technologies GmbH (DE) | 2023-04-26 | — | — | EP | disclosed |
| EP-2294310-B1 | ASSISTANCE SYSTEM FOR A MOTOR VEHICLE, METHOD AND DATA CARRIER THEREFOR | BOSCH GMBH ROBERT (DE) | 2016-06-15 | — | — | EP | disclosed |
| EP-2807721-A2 | ELECTRIC MACHINE | Sew-Eurodrive GmbH & Co. KG (DE) | 2014-12-03 | — | — | EP | disclosed |
| WO-2013110451-A2 | ELECTRIC MACHINE | SEW-EURODRIVE GMBH & CO. KG (DE) | 2013-08-01 | — | — | WO | disclosed |
| EP-2294310-A1 | ASSISTANCE SYSTEM FOR A MOTOR VEHICLE, METHOD AND DATA CARRIER THEREFOR | Robert Bosch GmbH (DE) | 2011-03-16 | — | — | EP | disclosed |
| EP-2291828-A2 | METHOD FOR DEPICTING A STATE | Schaeffler Technologies AG & Co. KG (DE) | 2011-03-09 | — | — | EP | disclosed |
| WO-2009156221-A1 | ASSISTANCE SYSTEM FOR A MOTOR VEHICLE, METHOD AND DATA CARRIER THEREFOR | ROBERT BOSCH GMBH (DE) | 2009-12-30 | — | — | WO | disclosed |
| WO-2009152809-A2 | METHOD FOR DEPICTING A STATE | SCHAEFFLER KG (DE) | 2009-12-23 | — | — | WO | disclosed |
| US-20050256165-A1 | Doxepin analogs and methods of use thereof | HYPNION, INC. | 2005-11-17 | — | — | US | disclosed |
| US-20050239838-A1 | Methods of treating sleep disorders | HYPNION, INC. | 2005-10-27 | — | — | US | disclosed |
| US-20050171160-A1 | Doxepin analogs and methods of use thereof | HYPNION, INC. | 2005-08-04 | — | — | US | disclosed |
| WO-2004051276-A1 | MAGNETIC PARTICLES FOR SEPARATING MICROORGANISMS FROM TECHNICAL MEDIA | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2004-06-17 | — | — | WO | disclosed |
| EP-1378063-A2 | METHOD AND CIRCUIT FOR LINEARISING NON-LINEAR CURVES | Micro-Epsilon Messtechnik GmbH & Co. KG (DE) | 2004-01-07 | — | — | EP | disclosed |
| WO-2002084883-A2 | METHOD AND CIRCUIT FOR LINEARISING NON-LINEAR CURVES | MICRO-EPSILON MESSTECHNIK GMBH & CO. KG (DE) | 2002-10-24 | — | — | WO | disclosed |
| WO-2001052026-A1 | PLUG-IN POWER PACK FOR SUPPLYING POWER TO SMALL ELECTRICAL CONSUMERS | SIEMENS AKTIENGESELLSCHAFT (DE) | 2001-07-19 | — | — | WO | disclosed |
| EP-0733343-B1 | Bone rasp | ZEIM INGRID (DE) | 1999-09-01 | — | — | EP | disclosed |
| EP-0733343-A1 | Shaping rasp for medical use | Kessel Werkzeugbau (DE) | 1996-09-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050171160-A1 | Doxepin analogs and methods of use thereof | MME, DPEP1, CES2 | GABRA1 1009/4885GABRB1 979/4885GABRG2 1871/4885 |
| US-20050256165-A1 | Doxepin analogs and methods of use thereof | MME, DPEP1, CES2 | GABRA1 1009/4885GABRB1 979/4885GABRG2 1871/4885 |
| US-20050239838-A1 | Methods of treating sleep disorders | HRH3, HNMT, HCRTR2 | GABRA1 545/4885GABRB1 605/4885GABRG2 1083/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.