SCHEMBL1747710

SCHEMBL1747710

Clc1cc(C(Cl)(Cl)Cl)cnc1Cl

nearest known ligand 0.44

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.44
ALDH1A1 P00352 8/20 0.38
GAA P10253 1/20 0.36
HTT P42858 1/20 0.36
NPSR1 Q6W5P4 5/20 0.34
PLAU P00749 1/20 0.34
KDM4E B2RXH2 1/20 0.34
POLB P06746 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
TDP1 Q9NUW8 2/20 0.33
CYP3A4 P08684 1/20 0.33
MAPK1 P28482 1/20 0.33
L3MBTL1 Q9Y468 2/20 0.32
MAPT P10636 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29504068 1.00 TSHR (0.44) TSHRALDH1A1GAAHTTNPSR1
SCHEMBL10436701 0.83 ALDH1A1 (0.40) TSHRALDH1A1GAAHTTNPSR1
SCHEMBL10353556 0.83 ALDH1A1 (0.40) TSHRALDH1A1GAAHTTNPSR1
SCHEMBL10349184 0.82 ALDH1A1 (0.42) ALDH1A1GAAHTTNPSR1PLAU
SCHEMBL10349447 0.82 ALDH1A1 (0.42) ALDH1A1GAAHTTNPSR1PLAU
SCHEMBL10838155 0.82 TSHR (0.37) TSHRALDH1A1GAAHTTNPSR1
SCHEMBL7893865 0.80 ALDH1A1 (0.41) ALDH1A1GAAHTTNPSR1PLAU
SCHEMBL29414916 0.79 ALDH1A1 (0.56) ALDH1A1GAAHTTNPSR1PLAU
SCHEMBL120994 0.79 ALDH1A1 (0.56) ALDH1A1GAAHTTNPSR1PLAU
SCHEMBL13165466 0.79 ALDH1A1 (0.44) ALDH1A1GAAHTTNPSR1PLAU

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 370 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118164902-A Preparation method of 2, 3-dichloro-5-trichloromethyl pyridine compound 江苏优嘉植物保护有限公司 2024-06-11 CN claimed
CN-117567363-A Method for synthesizing 2, 3-dichloro-5-trichloromethyl pyridine rectifying still residue by recycling chlorination 宁夏瑞泰科技股份有限公司 2024-02-20 CN claimed
CN-113527192-B Preparation method of 2, 3-dichloro-5-trifluoromethyl pyridine 武威广达科技有限公司 2024-02-13 CN claimed
CN-113248423-B Preparation method of 2, 3-dichloro-5-trifluoromethyl pyridine 武威广达科技有限公司 2023-10-03 CN claimed
CN-115322145-A Efficient haloxyfop-methyl production method 潍坊新绿化工有限公司 2022-11-11 CN claimed
CN-113527192-A Preparation method of 2, 3-dichloro-5-trifluoromethylpyridine 武威广达科技有限公司 2021-10-22 CN claimed
CN-113248423-A Preparation method of 2, 3-dichloro-5-trifluoromethylpyridine 武威广达科技有限公司 2021-08-13 CN claimed
CN-112939853-A Synthetic method of 2, 3-dichloro-5-trichloromethylpyridine 江苏优嘉植物保护有限公司 2021-06-11 CN claimed
CN-109232400-B Method for continuously synthesizing 2, 3-dichloro-5-trifluoromethylpyridine 中触媒新材料股份有限公司 2020-10-27 CN claimed
CN-110590651-A Preparation method of 2-aminomethyl-3-chloro-5-trifluoromethylpyridine hydrochloride 南通雅本化学有限公司 2019-12-20 CN claimed
US-4480102-A 2,3-Difluoro-5-(trifluoromethyl)pyridine and methods of making and using the same THE DOW CHEMICAL COMPANY (US) 1984-10-30 US claimed
WO-1984004095-A1 PRODUCTION OF POLYCHLORINATED PYRIDINE MIXTURES BY LIQUID PHASE CHLORINATION OF BETA-PICOLINE OR BETA-PICOLINE HYDROCHLORIDE KALAMA CHEMICAL INC (US) 1984-10-25 WO claimed
WO-1984004094-A1 PRODUCTION OF POLYCHLORINATED PYRIDINE MIXTURES BY LIQUID PHASE CHLORINATION OF BETA-PICOLINE OR BETA-PICOLINE HYDROCHLORIDE KALAMA CHEMICAL INC (US) 1984-10-25 WO claimed
WO-1984004093-A1 PRODUCTION OF POLYCHLORINATED PYRIDINE MIXTURES BY LIQUID PHASE CHLORINATION OF 3,5-LUTIDINE OR 3,5-LUTIDINE HYDROCHLORIDE KALAMA CHEMICAL INC (US) 1984-10-25 WO claimed
EP-0107866-A2 Trihalomethylpyridine compounds IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1984-05-09 EP claimed
EP-0104715-A2 2,3-Difluoro-5-(trifluoromethyl)pyridine and method of making and using the same THE DOW CHEMICAL COMPANY (US) 1984-04-04 EP claimed
EP-0063872-A1 Process for the preparation of fluoromethyl pyridines and certain novel products obtained therefrom IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1982-11-03 EP claimed
EP-0060462-A1 Preparation of 2,3-dichloro-5-trichloromethylpyridine THE DOW CHEMICAL COMPANY (US) 1982-09-22 EP claimed
US-4331811-A Preparation of 2,3-dichloro-5-trichloromethylpyridine THE DOW CHEMICAL COMPANY (US) 1982-05-25 US claimed
US-4309548-A Chlorination of 2-chloro-5-trichloromethylpyridine THE DOW CHEMICAL COMPANY (US) 1982-01-05 US claimed