SCHEMBL17477265

SCHEMBL17477265

Cc1nc2c(F)cc(-c3nc(Nc4ccc5[nH]cc(C6=CCN(C)CC6)c5c4)ncc3F)cc2n1C(C)C

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 19/20 0.56
CDK1 P06493 13/20 0.56
CCNB1 P14635 10/20 0.56
CCNE1 P24864 9/20 0.56
CDK2 P24941 13/20 0.55
CDK6 Q00534 12/20 0.55
CDK7 P50613 6/20 0.55
CDK9 P50750 6/20 0.55
CCNA2 P20248 3/20 0.53
CCND3 P30281 3/20 0.53
KDR P35968 3/20 0.53
HDAC3 O15379 1/20 0.51
HDAC1 Q13547 1/20 0.51
HDAC10 Q969S8 1/20 0.51
HDAC6 Q9UBN7 1/20 0.51
EGFR P00533 3/20 0.50
CCNT1 O60563 2/20 0.48
NTRK1 P04629 2/20 0.48
BRAF P15056 2/20 0.48
MAPK8 P45983 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17485410 0.88 CDK4 (0.63) CDK4CDK1CCNB1CCNE1CDK2
SCHEMBL17485350 0.82 CDK4 (0.60) CDK4CDK1CCNB1CCNE1CDK2
SCHEMBL17489153 0.81 CDK4 (0.68) CDK4CDK1CCNB1CCNE1CDK2
SCHEMBL17485422 0.78 SLC6A4 (0.41)
SCHEMBL30399948 0.76 PLK4 (0.59) CDK4CDK1CCNB1CCNE1CDK2
SCHEMBL26174778 0.76 PLK4 (0.59) CDK4CDK1CCNB1CCNE1CDK2
Hydrochloric Acid SCHEMBL31371275 0.75 CDK4 (0.67) CDK4CDK1CCNB1CCNE1CDK2
SCHEMBL17489069 0.74 CDK4 (0.68) CDK4CDK1CCNB1CCNE1CDK2
SCHEMBL30631120 0.74 CDK4 (0.68) CDK4CDK1CCNB1CCNE1CDK2
SCHEMBL27089928 0.74 CDK4 (0.68) CDK4CDK1CCNB1CCNE1CDK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016015604-A1 COMPOUNDS AS CDK SMALL-MOLECULE INHIBITORS AND USES THEREOF SUNSHINE LAKE PHARMA CO., LTD. (CN) 2016-02-04 WO disclosed
WO-2016015604-A1 COMPOUNDS AS CDK SMALL-MOLECULE INHIBITORS AND USES THEREOF SUNSHINE LAKE PHARMA CO., LTD. (CN) 2016-02-04 WO disclosed