Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.51 |
| ▸ | BRD2 | P25440 | 1/20 | 0.50 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.50 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11535108 | 0.98 | BRD4 (0.50) | BRD4BRD2BRD3BRDTSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL17594935 | 0.92 | BRD4 (0.46) | BRD4BRD2BRD3BRDTSMN1; SMN2 | |
| SCHEMBL5068788 | 0.87 | CNR2 (0.56) | BRD4BRD2BRD3BRDTSMN1; SMN2 | |
| SCHEMBL11535104 | 0.85 | BRD4 (0.49) | BRD4BRD2BRD3BRDTSMN1; SMN2 | |
| SCHEMBL1522903 | 0.84 | CNR2 (0.57) | BRD4BRD2BRD3BRDTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL11537392 | 0.83 | CNR2 (0.56) | BRD4BRD2BRD3BRDTSMN1; SMN2 | |
| SCHEMBL10461123 | 0.83 | CNR2 (0.53) | BRD4BRD2BRD3BRDTRAB9A | |
| SCHEMBL18256948 | 0.82 | ALDH1A1 (0.60) | BRD4BRD2BRD3BRDTSMN1; SMN2 | |
| SCHEMBL22234668 | 0.82 | SMN1; SMN2 (0.46) | BRD4BRD2BRD3BRDTSMN1; SMN2 | |
| SCHEMBL4996448 | 0.82 | BRD4 (0.46) | BRD4BRD2BRD3BRDTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3174852-B1 | ARYLHYDRAZIDES CONTAINING A 2-PYRIDONE MOIETY AS SELECTIVE ANTIBACTERIAL AGENTS | ABAC THERAPEUTICS S L (ES) | 2018-07-18 | — | — | EP | claimed |
| US-9840467-B2 | Arylhydrazides containing a 2-pyridone moiety as selective antibacterial agents | ABAC Therapeutics, S.L. (ES) | 2017-12-12 | — | — | US | claimed |
| US-20170217887-A1 | ARYLHYDRAZIDES CONTAINING A 2-PYRIDONE MOIETY AS SELECTIVE ANTIBACTERIAL AGENTS | ABAC Therapeutics, S.L. (ES) | 2017-08-03 | — | — | US | claimed |
| EP-3174852-A1 | ARYLHYDRAZIDES CONTAINING A 2-PYRIDONE MOIETY AS SELECTIVE ANTIBACTERIAL AGENTS | ABAC THERAPEUTICS, S.L. (ES) | 2017-06-07 | — | — | EP | claimed |
| CN-106660962-A | Arylhydrazides containing 2-pyridone moieties for use as selective antibacterial agents | ABAC治疗法有限公司 | 2017-05-10 | — | — | CN | claimed |
| WO-2016016291-A1 | ARYLHYDRAZIDES CONTAINING A 2-PYRIDONE MOIETY AS SELECTIVE ANTIBACTERIAL AGENTS | FERRER INTERNACIONAL, S.A. (ES) | 2016-02-04 | — | — | WO | claimed |
| EP-3436461-B1 | PYRROLOTRIAZINE COMPOUNDS AS TAM INHIBITORS | INCYTE CORP (US) | 2023-11-01 | — | — | EP | disclosed |
| US-10899772-B2 | IRAK4 modulators | GENENTECH, INC. (US) | 2021-01-26 | — | — | US | disclosed |
| EP-3642201-A1 | ISOINDOLINONE DERIVATIVES AS IRAK4 MODULATORS | H. Hoffnabb-La Roche Ag (CH) | 2020-04-29 | — | — | EP | disclosed |
| US-20200115383-A1 | IRAK4 MODULATORS | GENENTECH, INC. (US) | 2020-04-16 | — | — | US | disclosed |
| CN-110785418-A | Isoindolinone derivatives as IRAK4 modulators | 豪夫迈·罗氏有限公司 | 2020-02-11 | — | — | CN | disclosed |
| WO-2018234342-A1 | ISOINDOLINONE DERIVATIVES AS IRAK4 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2018-12-27 | — | — | WO | disclosed |
| EP-3174852-B1 | ARYLHYDRAZIDES CONTAINING A 2-PYRIDONE MOIETY AS SELECTIVE ANTIBACTERIAL AGENTS | ABAC THERAPEUTICS S L (ES) | 2018-07-18 | — | — | EP | disclosed |
| US-20170217887-A1 | ARYLHYDRAZIDES CONTAINING A 2-PYRIDONE MOIETY AS SELECTIVE ANTIBACTERIAL AGENTS | ABAC Therapeutics, S.L. (ES) | 2017-08-03 | — | — | US | disclosed |
| US-20170217887-A1 | ARYLHYDRAZIDES CONTAINING A 2-PYRIDONE MOIETY AS SELECTIVE ANTIBACTERIAL AGENTS | ABAC Therapeutics, S.L. (ES) | 2017-08-03 | — | — | US | disclosed |
| US-20170217887-A1 | ARYLHYDRAZIDES CONTAINING A 2-PYRIDONE MOIETY AS SELECTIVE ANTIBACTERIAL AGENTS | ABAC Therapeutics, S.L. (ES) | 2017-08-03 | — | — | US | disclosed |
| EP-3174852-A1 | ARYLHYDRAZIDES CONTAINING A 2-PYRIDONE MOIETY AS SELECTIVE ANTIBACTERIAL AGENTS | ABAC THERAPEUTICS, S.L. (ES) | 2017-06-07 | — | — | EP | disclosed |
| CN-106660962-A | Arylhydrazides containing 2-pyridone moieties for use as selective antibacterial agents | ABAC治疗法有限公司 | 2017-05-10 | — | — | CN | disclosed |
| WO-2016016291-A1 | ARYLHYDRAZIDES CONTAINING A 2-PYRIDONE MOIETY AS SELECTIVE ANTIBACTERIAL AGENTS | FERRER INTERNACIONAL, S.A. (ES) | 2016-02-04 | — | — | WO | disclosed |
| WO-2016016291-A1 | ARYLHYDRAZIDES CONTAINING A 2-PYRIDONE MOIETY AS SELECTIVE ANTIBACTERIAL AGENTS | FERRER INTERNACIONAL, S.A. (ES) | 2016-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170217887-A1 | ARYLHYDRAZIDES CONTAINING A 2-PYRIDONE MOIETY AS SELECTIVE ANTIBACTERIAL AGENTS | ABCC5, AAAS, PDXK | BRD4 53/4885BRD2 46/4885BRD3 192/4885 |
| US-20200115383-A1 | IRAK4 MODULATORS | IRAK4, IRAK1, IRAK2 | BRD4 198/4885BRD2 1429/4885BRD3 1199/4885 |
| US-10899772-B2 | IRAK4 modulators | IRAK4, IRAK1, IRAK2 | BRD4 198/4885BRD2 1429/4885BRD3 1199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.