Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 8/20 | 0.38 |
| ▸ | CDC25B | P30305 | 8/20 | 0.38 |
| ▸ | PTPN2 | P17706 | 4/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 4/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 4/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | TACR2 | P21452 | 2/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | NT5E | P21589 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.34 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.34 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.34 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17453458 | 1.00 | HTR1A (0.41) | HTR1APTPN1CDC25BPTPN2PTPN6 | |
| SCHEMBL29788383 | 0.92 | HTR1A (0.38) | HTR1APTPN1CDC25BPTPN2PTPN6 | |
| SCHEMBL22319414 | 0.92 | HTR1A (0.38) | HTR1APTPN1CDC25BPTPN2PTPN6 | |
| SCHEMBL21136856 | 0.92 | HTR1A (0.38) | HTR1APTPN1CDC25BPTPN2PTPN6 | |
| SCHEMBL17453485 | 0.92 | PDE2A (0.41) | HTR1APTPN1CDC25BPTPN2PTPN6 | |
| SCHEMBL29788347 | 0.92 | PDE2A (0.41) | HTR1APTPN1CDC25BPTPN2PTPN6 | |
| SCHEMBL26812522 | 0.85 | PDE2A (0.45) | HTR1APTPN1CDC25BPTPN2PTPN6 | |
| SCHEMBL21137107 | 0.85 | PDE2A (0.45) | HTR1APTPN1CDC25BPTPN2PTPN6 | |
| SCHEMBL17465408 | 0.84 | HPGD (0.30) | — | |
| SCHEMBL17468792 | 0.83 | LTA4H (0.34) | SSTR1SSTR2SSTR4SSTR3SSTR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3174870-A1 | THIENO [3,2-D]PYRIMIDINE, FURO [3,2,D]PYRIMIDINE, AND PYRROLO [3,2-D]PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | Gilead Sciences, Inc. (US) | 2017-06-07 | — | — | EP | disclosed |
| WO-2016018697-A1 | THIENO [3,2-D] PYRIMIDINE, FURO [3,2,D] PYRIMIDINE, AND PYRROLO [3,2-D] PYRIMIDINES USEFUL FOR TREATING RESPIRATORY SYNCITIAL VIRUS INFECTIONS | GILEAD SCIENCES, INC. (US) | 2016-02-04 | — | — | WO | disclosed |