Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 17/20 | 0.46 |
| ▸ | CHUK | O15111 | 7/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17484105 | 0.84 | PLK1 (0.44) | PLK1IKBKBCHUK | |
| SCHEMBL16081472 | 0.77 | IKBKB (0.54) | PLK1SYKIKBKBCHUK | |
| SCHEMBL17484071 | 0.77 | KDR (0.59) | PLK1SYKIKBKBCHUK | |
| SCHEMBL14500600 | 0.72 | CDK9 (0.46) | — | |
| SCHEMBL16081631 | 0.72 | EHMT2 (0.44) | — | |
| Hydrochloric Acid SCHEMBL5661887 | 0.72 | CDK9 (0.46) | — | |
| SCHEMBL17481590 | 0.70 | NPC1 (0.52) | PLK1SYKIKBKBCHUK | |
| SCHEMBL13035473 | 0.69 | SYK (0.64) | PLK1SYKIKBKBCHUK | |
| SCHEMBL23906535 | 0.69 | EHMT2 (0.40) | PLK1IKBKB | |
| SCHEMBL30086911 | 0.69 | EHMT2 (0.40) | PLK1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9963452-B2 | Methods, compounds, and compositions for inhibition of ROS | AUGUSTA PHARMACEUTICALS INC. (US) | 2018-05-08 | — | — | US | disclosed |
| US-20160031890-A1 | NOVEL METHODS, COMPOUNDS, AND COMPOSITIONS FOR INHIBITION OF ROS | GRUENEBERG, Dorre A. | 2016-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160031890-A1 | NOVEL METHODS, COMPOUNDS, AND COMPOSITIONS FOR INHIBITION OF ROS | ROS1, NOX4, NOX1 | PLK1 179/4885SYK 283/4885IKBKB 1115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.