Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.44 |
| ▸ | PNMT | P11086 | 3/20 | 0.44 |
| ▸ | CD44 | P16070 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.42 |
| ▸ | HTR5A | P47898 | 1/20 | 0.42 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.42 |
| ▸ | GPR3 | P46089 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31503196 | 0.84 | KDM4E (0.42) | HTR2CPNMTKDM4EGPR3PARP1 | |
| SCHEMBL31164716 | 0.78 | PNMT (0.49) | HTR2CPNMTHTR2AADRB2NCF1 | |
| SCHEMBL30184315 | 0.78 | POLB (0.40) | HTR2CPNMTCD44MAOBKDM4E | |
| SCHEMBL9155402 | 0.75 | KDM4E (0.44) | KDM4EGPR3 | |
| SCHEMBL22744295 | 0.74 | SSTR4 (0.47) | HTR2CKDM4EGPR3 | |
| SCHEMBL17590022 | 0.74 | PNMT (0.36) | HTR2CPNMTCD44MAOBHTR2A | |
| SCHEMBL22744581 | 0.73 | SSTR4 (0.36) | HTR2CKDM4EGPR3TAAR1PARP1 | |
| SCHEMBL29997743 | 0.72 | GPR3 (0.48) | KDM4EGPR3PARP1NCF1 | |
| SCHEMBL25263696 | 0.72 | AURKA (0.40) | HTR2CPNMTCD44MAOB | |
| SCHEMBL30381048 | 0.72 | AURKA (0.40) | HTR2CPNMTCD44MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9255096-B1 | Substituted 1,2,3,4-tetrahydrobenzo[C][2,7] naphthyridines and derivatives thereof as kinase inhibitors | ALLERGAN, INC. (US) | 2016-02-09 | — | — | US | disclosed |
| US-9255096-B1 | Substituted 1,2,3,4-tetrahydrobenzo[C][2,7] naphthyridines and derivatives thereof as kinase inhibitors | ALLERGAN, INC. (US) | 2016-02-09 | — | — | US | disclosed |
| US-9255096-B1 | Substituted 1,2,3,4-tetrahydrobenzo[C][2,7] naphthyridines and derivatives thereof as kinase inhibitors | ALLERGAN, INC. (US) | 2016-02-09 | — | — | US | disclosed |