Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 1.00 |
| ▸ | HTT | P42858 | 4/20 | 1.00 |
| ▸ | RAB9A | P51151 | 4/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | NPC1 | O15118 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | STAT1 | P42224 | 1/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.78 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.70 |
| ▸ | CDK8 | P49336 | 1/20 | 0.70 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.65 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.65 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6100788 | 0.85 | ALDH1A1 (0.80) | ALDH1A1HTTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL426655 | 0.83 | CDK8 (1.00) | ALDH1A1HTTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL12562445 | 0.83 | ALDH1A1 (0.80) | ALDH1A1HTTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL16071457 | 0.82 | ALDH1A1 (0.72) | ALDH1A1HTTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL429541 | 0.80 | ALDH1A1 (1.00) | ALDH1A1HTTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8242756 | 0.80 | ALDH1A1 (0.74) | ALDH1A1HTTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8242540 | 0.80 | ALDH1A1 (0.74) | ALDH1A1HTTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL8238314 | 0.74 | ALDH1A1 (0.65) | ALDH1A1HTTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL4658096 | 0.74 | CDK8 (0.68) | ALDH1A1HTTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL14110701 | 0.74 | ALDH1A1 (0.62) | ALDH1A1HTTRAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210220408-A1 | ARYL HYDROCARBON RECEPTOR ANTAGONISTS AND METHODS OF USE | EDIGENE BIOTECHNOLOGY, INC. (CN) | 2021-07-22 | — | — | US | disclosed |
| US-9707210-B2 | Methods of treating muscular dystrophy | BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, RENO (US) | 2017-07-18 | — | — | US | disclosed |
| US-20160030390-A1 | METHODS OF TREATING MUSCULAR DYSTROPHY | Board of Regents of the Nevada System of Higher Ed ucation on behalf of the University of Nevada Ren (US) | 2016-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160030390-A1 | METHODS OF TREATING MUSCULAR DYSTROPHY | ITGB7, ITGA2B, ITGB1 | ALDH1A1 342/4885HTT 4298/4885RAB9A 1131/4885 |
| US-20210220408-A1 | ARYL HYDROCARBON RECEPTOR ANTAGONISTS AND METHODS OF USE | AHR, ARNT, ARSA | ALDH1A1 98/4885HTT 687/4885RAB9A 4056/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.