Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 8/20 | 0.33 |
| ▸ | KDR | P35968 | 6/20 | 0.33 |
| ▸ | RAF1 | P04049 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 2/20 | 0.32 |
| ▸ | TEK | Q02763 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.32 |
| ▸ | SCD | O00767 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | STK25 | O00506 | 1/20 | 0.31 |
| ▸ | CIT | O14578 | 1/20 | 0.31 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.31 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.31 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.31 |
| ▸ | PAK3 | O75914 | 1/20 | 0.31 |
| ▸ | STK10 | O94804 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17488049 | 0.94 | MAPT (0.34) | BRAFKDRRAF1TP53GAA | |
| SCHEMBL17488319 | 0.90 | TP53 (0.39) | BRAFKDRRAF1TP53MCHR1 | |
| SCHEMBL18965883 | 0.86 | KDR (0.35) | BRAFKDRRAF1TP53MCHR1 | |
| SCHEMBL18965823 | 0.86 | NTRK1 (0.46) | BRAFKDRRAF1JAK3NTRK1 | |
| SCHEMBL18965884 | 0.84 | LMNA (0.39) | TP53GAAMAPTLMNASCD | |
| SCHEMBL17488323 | 0.83 | MCHR1 (0.40) | BRAFKDRRAF1TP53MCHR1 | |
| SCHEMBL17488247 | 0.83 | LMNA (0.38) | BRAFKDRTP53GAAMAPT | |
| SCHEMBL17488050 | 0.82 | TP53 (0.40) | BRAFKDRRAF1TP53MCHR1 | |
| SCHEMBL17488231 | 0.81 | SCN9A (0.34) | KDRTP53MCHR1GAAMAPT | |
| SCHEMBL17488053 | 0.80 | MCHR1 (0.40) | BRAFKDRRAF1MCHR1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016016421-A1 | 2-AMINO-BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS 5-LIPOXYGENASE AND/OR PROSTAGLANDIN E SYNTHASE INHIBITORS | INSTITUT PASTEUR KOREA (KR) | 2016-02-04 | — | — | WO | disclosed |