Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 1/20 | 0.57 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 2/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17488073 | 0.92 | CXCL8 (0.57) | CXCL8NOD1KMT2ATP53SMN1; SMN2 | |
| SCHEMBL18965837 | 0.86 | SMN1; SMN2 (0.40) | CXCL8NOD1TP53SMN1; SMN2HTT | |
| SCHEMBL17488298 | 0.84 | SOS1 (0.46) | CXCL8NOD1KMT2AHTTALDH1A1 | |
| SCHEMBL17488296 | 0.79 | P2RX3 (0.41) | CXCL8NOD1 | |
| SCHEMBL18960394 | 0.78 | SMN1; SMN2 (0.40) | CXCL8NOD1KMT2ATP53SMN1; SMN2 | |
| SCHEMBL18965766 | 0.71 | NPC1 (0.50) | KMT2ATP53SMN1; SMN2HTTMAPT | |
| SCHEMBL18965845 | 0.71 | CYP3A4 (0.41) | TP53ALDH1A1LMNA | |
| SCHEMBL17487771 | 0.70 | P2RX3 (0.42) | NOD1SMN1; SMN2HTTLMNANPSR1 | |
| SCHEMBL17488212 | 0.70 | CYP3A4 (0.41) | TP53ALDH1A1LMNA | |
| SCHEMBL18965928 | 0.70 | CYP3A4 (0.38) | KMT2ASMN1; SMN2MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016016421-A1 | 2-AMINO-BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS 5-LIPOXYGENASE AND/OR PROSTAGLANDIN E SYNTHASE INHIBITORS | INSTITUT PASTEUR KOREA (KR) | 2016-02-04 | — | — | WO | disclosed |