Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 11/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17488046 | 0.93 | LMNA (0.40) | LMNATP53P2RX3THRBSMN1; SMN2 | |
| SCHEMBL17487851 | 0.92 | NPC1 (0.39) | TP53SMN1; SMN2NPC1RAB9AGAA | |
| SCHEMBL17488256 | 0.91 | CYP3A4 (0.39) | LMNATP53P2RX3 | |
| SCHEMBL17487846 | 0.89 | LMNA (0.41) | LMNATP53P2RX3THRBSMN1; SMN2 | |
| SCHEMBL18965877 | 0.89 | TP53 (0.39) | LMNATP53P2RX3THRBSMN1; SMN2 | |
| SCHEMBL18965884 | 0.85 | LMNA (0.39) | LMNATP53P2RX3THRBSMN1; SMN2 | |
| SCHEMBL17488325 | 0.85 | DHODH (0.42) | LMNATP53THRBSMN1; SMN2NPC1 | |
| SCHEMBL17488140 | 0.85 | PIK3C3 (0.40) | TP53P2RX3SMN1; SMN2NPC1RAB9A | |
| SCHEMBL17487532 | 0.83 | PLK4 (0.40) | PIK3C3 | |
| SCHEMBL18965976 | 0.82 | LMNA (0.41) | LMNATP53P2RX3THRBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016016421-A1 | 2-AMINO-BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS 5-LIPOXYGENASE AND/OR PROSTAGLANDIN E SYNTHASE INHIBITORS | INSTITUT PASTEUR KOREA (KR) | 2016-02-04 | — | — | WO | disclosed |