Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 11/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 9/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 7/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.33 |
| ▸ | ESYT2 | A0FGR8 | 1/20 | 0.31 |
| ▸ | HACL2 | A1L0T0 | 1/20 | 0.31 |
| ▸ | NBAS | A2RRP1 | 1/20 | 0.31 |
| ▸ | GTPBP10 | A4D1E9 | 1/20 | 0.31 |
| ▸ | CNOT1 | A5YKK6 | 1/20 | 0.31 |
| ▸ | TBKBP1 | A7MCY6 | 1/20 | 0.31 |
| ▸ | AGPS | O00116 | 1/20 | 0.31 |
| ▸ | ACOT7 | O00154 | 1/20 | 0.31 |
| ▸ | MYO1F | O00160 | 1/20 | 0.31 |
| ▸ | SNAP23 | O00161 | 1/20 | 0.31 |
| ▸ | HAX1 | O00165 | 1/20 | 0.31 |
| ▸ | AIP | O00170 | 1/20 | 0.31 |
| ▸ | AP3B1 | O00203 | 1/20 | 0.31 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.31 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.31 |
| ▸ | PSMD9 | O00233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL174494 | 0.84 | PLK4 (0.46) | ADORA3PLK4AURKAPAK4NTRK1 | |
| SCHEMBL174445 | 0.77 | CCNE2 (0.44) | ALDH1A1LMNANTRK1CDK4CCNE1 | |
| SCHEMBL174490 | 0.77 | AURKB (0.41) | AURKANTRK1LCKCCNE1GRK6 | |
| SCHEMBL12105313 | 0.76 | TRPA1 (0.30) | TRPA1 | |
| SCHEMBL174171 | 0.76 | NTRK1 (0.41) | AURKANTRK1AURKB | |
| SCHEMBL175164 | 0.75 | MEN1 (0.38) | LCKAURKB | |
| SCHEMBL174795 | 0.75 | FLT3 (0.36) | PLK4AURKAPAK4ALDH1A1NTRK1 | |
| SCHEMBL164859 | 0.75 | ADORA3 (0.43) | ADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL166125 | 0.75 | ADORA2A (0.54) | ADORA3ADORA2AADORA1ADORA2B | |
| SCHEMBL173271 | 0.74 | AURKB (0.44) | AURKAALDH1A1EGFRNTRK1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130303533-A1 | AZOLOPYRIDINE AND AZOLOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2013-11-14 | — | — | US | claimed |
| EP-2611809-A1 | AZOLOPYRIDINE AND AZOLOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2013-07-10 | — | — | EP | claimed |
| WO-2012030924-A1 | AZOLOPYRIDINE AND AZOLOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2012-03-08 | — | — | WO | claimed |
| US-20130303533-A1 | AZOLOPYRIDINE AND AZOLOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2013-11-14 | — | — | US | disclosed |
| US-20130303533-A1 | AZOLOPYRIDINE AND AZOLOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2013-11-14 | — | — | US | disclosed |
| US-20130303533-A1 | AZOLOPYRIDINE AND AZOLOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2013-11-14 | — | — | US | disclosed |
| EP-2611809-A1 | AZOLOPYRIDINE AND AZOLOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030924-A1 | AZOLOPYRIDINE AND AZOLOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2012-03-08 | — | — | WO | disclosed |
| WO-2012030924-A1 | AZOLOPYRIDINE AND AZOLOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2012-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130303533-A1 | AZOLOPYRIDINE AND AZOLOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | JAK3, JAK2, JAK1 | ADORA3 1302/4885ADORA2A 1933/4885ADORA1 3035/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.