Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 8/20 | 0.44 |
| ▸ | PPARG | P37231 | 7/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 6/20 | 0.39 |
| ▸ | CTSK | P43235 | 5/20 | 0.39 |
| ▸ | PPARD | Q03181 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL113493 | 0.80 | SYK (0.44) | PPARAPPARGATMCTSSCTSK | |
| SCHEMBL5558096 | 0.78 | PPARG (0.47) | PPARAPPARGATMCTSSCTSK | |
| SCHEMBL113413 | 0.76 | SYK (0.43) | PPARACTSSCTSKSYKPARP1 | |
| SCHEMBL112405 | 0.73 | PARP1 (0.36) | PPARAPPARGPARP1 | |
| SCHEMBL115439 | 0.73 | PPARA (0.39) | PPARAPPARGCTSSCTSKSYK | |
| SCHEMBL175265 | 0.73 | SYK (0.44) | SYKPARP1 | |
| SCHEMBL9880876 | 0.70 | AKR1C3 (0.43) | PARP1 | |
| SCHEMBL165852 | 0.70 | SYK (0.43) | PPARAPPARGATMCTSSCTSK | |
| SCHEMBL8535989 | 0.69 | CTSS (0.49) | ATMCTSSCTSK | |
| SCHEMBL25192516 | 0.68 | PPARA (0.48) | PPARAPPARGCTSSCTSKPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424842-A2 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | Aerie Pharmaceuticals, Inc. (US) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010126626-A2 | DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE | AERIE PHARMACEUTICALS, INC. (US) | 2010-11-04 | — | — | WO | disclosed |