Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.41 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 6/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CD4 | P01730 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP7 | P09237 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP12 | P39900 | 1/20 | 0.34 |
| ▸ | MMP14 | P50281 | 1/20 | 0.34 |
| ▸ | MMP15 | P51511 | 1/20 | 0.34 |
| ▸ | MMP16 | P51512 | 1/20 | 0.34 |
| ▸ | MMP26 | Q9NRE1 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17498183 | 0.81 | MAPT (0.34) | MAPTTDP1PPARG | |
| SCHEMBL17498105 | 0.80 | MAPT (0.35) | MAPTHTR6TDP1PPARG | |
| SCHEMBL17498143 | 0.78 | MAPT (0.35) | MAPTTDP1PPARG | |
| SCHEMBL17498154 | 0.76 | MAPT (0.39) | MAPTTDP1PPARG | |
| SCHEMBL17498069 | 0.70 | USP2 (0.40) | TRIM24TRIM33MAPTHTR6TDP1 | |
| SCHEMBL17498109 | 0.70 | CYP19A1 (0.40) | MAPTTDP1 | |
| SCHEMBL30984278 | 0.69 | HTR6 (0.49) | HDAC1HDAC6HTR6BCHE | |
| SCHEMBL17498131 | 0.67 | MAPT (0.38) | MAPTTDP1PPARG | |
| SCHEMBL17498186 | 0.67 | GRM5 (0.33) | MAPTPPARG | |
| SCHEMBL17495071 | 0.66 | MAPT (0.44) | MAPTTDP1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016025933-A2 | SUBSTITUTED POLYCYCLIC ANTIBACTERIAL COMPOUNDS | PTC THERAPEUTICS, INC. (US) | 2016-02-18 | — | — | WO | disclosed |