SCHEMBL17499306

SCHEMBL17499306

Cc1ccc(N=C(c2ccccc2)c2ncccc2C)c(O[SiH](C)C)c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.33
KMT2A Q03164 5/20 0.33
ALDH1A1 P00352 4/20 0.33
MEN1 O00255 3/20 0.33
SMN1; SMN2 Q16637 4/20 0.32
HTT P42858 3/20 0.32
TDP1 Q9NUW8 3/20 0.32
KDM4E B2RXH2 2/20 0.32
MAPK1 P28482 2/20 0.32
NPC1 O15118 2/20 0.32
HSP90AA1 P07900 1/20 0.32
MMP14 P50281 1/20 0.32
AGTR1 P30556 1/20 0.32
ESR1 P03372 1/20 0.32
ESR2 Q92731 1/20 0.32
RAB9A P51151 3/20 0.31
MITF O75030 1/20 0.31
LMNA P02545 1/20 0.31
TP53 P04637 1/20 0.31
NPSR1 Q6W5P4 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17499290 0.89 ESR2 (0.37) MAPTKMT2AALDH1A1MEN1SMN1; SMN2
SCHEMBL17499388 0.88 ALDH1A1 (0.33) MAPTKMT2AALDH1A1MEN1
SCHEMBL16097187 0.87 HTT (0.41) MAPTKMT2AALDH1A1MEN1SMN1; SMN2
SCHEMBL28040336 0.87 ALDH1A1 (0.32) MAPTKMT2AALDH1A1MEN1
SCHEMBL17499195 0.86 MAPT (0.35) MAPTKMT2AALDH1A1MEN1SMN1; SMN2
SCHEMBL17499521 0.86 TBXA2R (0.38) MAPTKMT2AALDH1A1MEN1SMN1; SMN2
SCHEMBL17499470 0.85 SMN1; SMN2 (0.35) MAPTKMT2AALDH1A1MEN1SMN1; SMN2
SCHEMBL17499353 0.84 RAB9A (0.43) MAPTKMT2AALDH1A1MEN1SMN1; SMN2
SCHEMBL17499277 0.80 TBXA2R (0.43) MAPTKMT2AALDH1A1MEN1SMN1; SMN2
SCHEMBL16104946 0.79 ALDH1A1 (0.34) MAPTKMT2AALDH1A1MEN1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2969593-B1 POLYMERS FUNCTIONALIZED WITH HETEROCYCLIC IMINES BRIDGESTONE CORP (JP) 2020-11-04 EP disclosed
US-9850328-B2 Polymers functionalized with heterocyclic imines BRIDGESTONE CORPORATION (JP) 2017-12-26 US disclosed
US-20160039958-A1 Polymers Functionalized With Heterocyclic Imines BRIDGESTONE CORPORATION (JP) 2016-02-11 US disclosed