SCHEMBL17499491

SCHEMBL17499491

C[Si](C)(C)Oc1ccccc1CCN=Cc1ncncn1

nearest known ligand 0.33

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ABCB1 P08183 3/20 0.33
BCHE P06276 1/20 0.32
SHBG P04278 1/20 0.32
HTR1A P08908 2/20 0.32
DRD2 P14416 2/20 0.32
USP2 O75604 1/20 0.31
ALDH1A1 P00352 1/20 0.31
LMNA P02545 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
CYP2C9 P11712 1/20 0.31
TSHR P16473 1/20 0.31
CYP2C19 P33261 1/20 0.31
HIF1A Q16665 1/20 0.31
CLK4 Q9HAZ1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16097198 0.89 ABCB1 (0.36) ABCB1BCHESHBGHTR1ADRD2
SCHEMBL17499117 0.86 GRIN1 (0.32) ALDH1A1
SCHEMBL16097182 0.86 TAAR1 (0.44) ABCB1BCHESHBGUSP2ALDH1A1
SCHEMBL17499119 0.86 GRIN1 (0.32) ALDH1A1
SCHEMBL17499317 0.86 BCHE (0.32) ABCB1BCHESHBGHTR1ADRD2
SCHEMBL16095976 0.84 ABCB1 (0.33) ABCB1
SCHEMBL17499140 0.82 SHBG (0.34) SHBGUSP2ALDH1A1LMNACYP1A2
SCHEMBL17499252 0.80 CA1 (0.41) ABCB1SHBGALDH1A1LMNA
SCHEMBL17499557 0.79 NR4A1 (0.39) ABCB1HTR1ADRD2USP2ALDH1A1
SCHEMBL17499185 0.79 MEN1 (0.37) ABCB1HTR1ADRD2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9850328-B2 Polymers functionalized with heterocyclic imines BRIDGESTONE CORPORATION (JP) 2017-12-26 US disclosed
US-20160039958-A1 Polymers Functionalized With Heterocyclic Imines BRIDGESTONE CORPORATION (JP) 2016-02-11 US disclosed