SCHEMBL17499655

SCHEMBL17499655

CC(=Nc1c(C)cccc1O[SiH](C)C)c1ncccn1

nearest known ligand 0.33

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PLAU P00749 2/20 0.33
KDM4E B2RXH2 1/20 0.30
GAA P10253 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17499221 0.85 KDM4E (0.44) KDM4EGAAMAPT
SCHEMBL16102025 0.84 PLAU (0.42) PLAUKDM4EGAAMAPT
SCHEMBL5587104 0.82 PLAU (0.42) PLAUKDM4EMAPT
SCHEMBL17499742 0.82 PLAU (0.33) PLAUKDM4EGAAMAPT
SCHEMBL17499802 0.82 TBXA2R (0.36) PLAUKDM4EMAPT
SCHEMBL17499417 0.81 KMT2A (0.38) KDM4EGAAMAPT
SCHEMBL5693492 0.80 PLAU (0.41) PLAUKDM4EMAPT
SCHEMBL28858395 0.80 KMT2A (0.37) KDM4EGAAMAPT
SCHEMBL16097745 0.79
SCHEMBL17499527 0.78 KDM4E (0.37) PLAUKDM4EGAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2969593-B1 POLYMERS FUNCTIONALIZED WITH HETEROCYCLIC IMINES BRIDGESTONE CORP (JP) 2020-11-04 EP disclosed
US-9850328-B2 Polymers functionalized with heterocyclic imines BRIDGESTONE CORPORATION (JP) 2017-12-26 US disclosed
US-20160039958-A1 Polymers Functionalized With Heterocyclic Imines BRIDGESTONE CORPORATION (JP) 2016-02-11 US disclosed