Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 3/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17500115 | 1.00 | SMYD3 (0.36) | SMYD3ACHEATMALDH1A1LMNA | |
| SCHEMBL17374313 | 0.82 | KMT2A (0.46) | — | |
| SCHEMBL26601146 | 0.79 | SMYD3 (0.37) | SMYD3ACHEOPRK1 | |
| SCHEMBL26601141 | 0.79 | SMYD3 (0.37) | SMYD3ACHEOPRK1 | |
| SCHEMBL21410750 | 0.77 | ACHE (0.37) | ACHE | |
| SCHEMBL17500142 | 0.77 | SMYD3 (0.36) | SMYD3ACHELMNAOPRK1 | |
| SCHEMBL17500144 | 0.77 | SMYD3 (0.36) | SMYD3ACHELMNAOPRK1 | |
| SCHEMBL31115833 | 0.75 | ACHE (0.36) | ACHE | |
| SCHEMBL17874277 | 0.75 | PSMB8 (0.35) | SMYD3ACHE | |
| SCHEMBL21410602 | 0.75 | ACHE (0.39) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017040606-A1 | ISOXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PULMONARY DISEASES AND DISORDERS | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2017-03-09 | — | — | WO | disclosed |
| WO-2016115090-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR INCREASING CFTR ACTIVITY | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2016-07-21 | — | — | WO | disclosed |
| WO-2015196071-A9 | COMPOUNDS, COMPOSITIONS AND METHODS OF INCREASING CFTR ACTIVITY | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2016-02-18 | — | — | WO | disclosed |