Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MTHFD1 | P11586 | 2/20 | 0.38 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.37 |
| ▸ | FPGS | Q05932 | 2/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TYMS | P04818 | 3/20 | 0.33 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.32 |
| ▸ | ATIC | P31939 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17500356 | 1.00 | DHFR (0.57) | DHFRLMNAMTHFD1SOSTFPGS | |
| SCHEMBL22132529 | 0.93 | DHFR (0.55) | DHFRLMNAMTHFD1SOSTFPGS | |
| SCHEMBL14025589 | 0.88 | DHFR (0.60) | DHFRLMNAMTHFD1SOSTFPGS | |
| Leucovorin SCHEMBL5132046 | 0.85 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTFPGS | |
| Leucovorin SCHEMBL21632556 | 0.85 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTFPGS | |
| SCHEMBL24240301 | 0.85 | DHFR (0.70) | DHFRLMNAMTHFD1SOSTFPGS | |
| Leucovorin SCHEMBL8349 | 0.85 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTFPGS | |
| SCHEMBL6126743 | 0.85 | DHFR (0.54) | DHFRLMNAMTHFD1SOSTFPGS | |
| Leucovorin SCHEMBL571902 | 0.85 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTFPGS | |
| Leucovorin SCHEMBL8350 | 0.85 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTFPGS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180237781-A1 | COMPOSITIONS AND METHODS FOR REGULATION OF GENE EXPRESSION WITH, AND DETECTION OF, FOLINIC ACID AND FOLATES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2018-08-23 | — | — | US | claimed |
| WO-2016025750-A2 | COMPOSITIONS AND METHODS FOR REGULATION OF GENE EXPRESSION WITH, AND DETECTION OF, FOLINIC ACID AND FOLATES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2016-02-18 | — | — | WO | claimed |
| US-20200255835-A1 | COMPOSITIONS AND METHODS FOR REGULATION OF GENE EXPRESSION WITH, AND DETECTION OF, FOLINIC ACID AND FOLATES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY | 2020-08-13 | — | — | US | disclosed |
| US-10450573-B2 | Compositions and methods for regulation of gene expression with, and detection of, folinic acid and folates | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2019-10-22 | — | — | US | disclosed |
| US-20180237781-A1 | COMPOSITIONS AND METHODS FOR REGULATION OF GENE EXPRESSION WITH, AND DETECTION OF, FOLINIC ACID AND FOLATES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2018-08-23 | — | — | US | disclosed |
| WO-2016025750-A2 | COMPOSITIONS AND METHODS FOR REGULATION OF GENE EXPRESSION WITH, AND DETECTION OF, FOLINIC ACID AND FOLATES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2016-02-18 | — | — | WO | disclosed |