Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 2/20 | 0.80 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | MTHFD1 | P11586 | 3/20 | 0.58 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.57 |
| ▸ | MTHFD2 | P13995 | 3/20 | 0.51 |
| ▸ | FPGS | Q05932 | 2/20 | 0.51 |
| ▸ | ATIC | P31939 | 2/20 | 0.51 |
| ▸ | TYMS | P04818 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucovorin SCHEMBL5132046 | 1.00 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTMTHFD2 | |
| Folinic Acid SCHEMBL29369091 | 1.00 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTMTHFD2 | |
| Leucovorin SCHEMBL21632556 | 1.00 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTMTHFD2 | |
| Leucovorin SCHEMBL4708750 | 1.00 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTMTHFD2 | |
| Leucovorin SCHEMBL8350 | 1.00 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTMTHFD2 | |
| Levoleucovorin SCHEMBL571901 | 1.00 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTMTHFD2 | |
| Leucovorin SCHEMBL571902 | 1.00 | DHFR (0.80) | DHFRLMNAMTHFD1SOSTMTHFD2 | |
| Leucovorin SCHEMBL9054117 | 0.99 | DHFR (0.78) | DHFRLMNAMTHFD1SOSTMTHFD2 | |
| Leucovorin SCHEMBL16207660 | 0.99 | DHFR (0.78) | DHFRLMNAMTHFD1SOSTMTHFD2 | |
| Leucovorin SCHEMBL9054183 | 0.99 | DHFR (0.78) | DHFRLMNAMTHFD1SOSTMTHFD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 87527 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260144750-A1 | Dosing Regimens for Treatment of Glioblastoma | SIGNPATH PHARMA INC. (US) | 2026-05-28 | — | — | US | claimed |
| EP-4746876-A1 | UDP-GLUCOSE CERAMIDE GLUCOSYLTRANSFERASE SYNTHASE (UGCG) INHIBITORS IN THE TREATMENT OF CANCER | Katholieke Universiteit Leuven (BE) | 2026-05-27 | — | — | EP | claimed |
| EP-4748859-A2 | CHEMICALLY AND PHOTOCHEMICALLY INITIATED CELL MEMBRANE BLEBBING TO INDUCE CELL VESICLE PRODUCTION, MODIFICATIONS THEREOF, AND USES THEREOF | The Regents of the University of California (US) | 2026-05-27 | — | — | EP | claimed |
| CN-122075411-A | Tripterine liposome, its combined medicine and its application in preventing and treating tumor | — | 2026-05-26 | — | — | CN | claimed |
| CN-122094686-A | Oncolytic adenovirus and topoisomerase I inhibitors for the treatment of cancer | — | 2026-05-26 | — | — | CN | claimed |
| US-12636320-B2 | Methods and agents for treating solid tumor cancers | SALSPERA, LLC (US) | 2026-05-26 | — | — | US | claimed |
| CN-122074090-A | Diversified phage synthesis and engineering platform | 修兰教育基金管理公司 | 2026-05-22 | — | — | CN | claimed |
| CN-122074048-A | Methods of treating cancer | 诺华股份有限公司 | 2026-05-22 | — | — | CN | claimed |
| US-20260137678-A1 | METHODS FOR TREATING OR PREVENTING NEUROENDOCRINE TUMOR FORMATION USING XPO1 INHIBITORS | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2026-05-21 | — | — | US | claimed |
| WO-2026103823-A1 | COMBINATION OF RAS INHIBITOR AND EGFR INHIBITOR AND USE THEREOF | 广州嘉越医药科技有限公司 | 2026-05-21 | — | — | WO | claimed |
| EP-0096560-B1 | ASSESSMENT OF NUTRITIONAL STATUS OF INDIVIDUALS | Clayton Foundation for Research (US) | 1987-05-06 | — | — | EP | claimed |
| US-4533637-A | REPLACING SERUM WITH CYCLODEXTRINS | AJINOMOTO CO., INC. (JP) | 1985-08-06 | — | — | US | claimed |
| US-4500711-A | Synthesis of leucovorin | BURROUGHS WELLCOME CO. (US) | 1985-02-19 | — | — | US | claimed |
| US-4499064-A | Assessment of nutritional status of individuals | CLAYTON FOUNDATION FOR RESEARCH (US) | 1985-02-12 | — | — | US | claimed |
| EP-0121399-A2 | A method for producing hybrids between myeloma cells and normal cells | BIO-RESPONSE INC. (US) | 1984-10-10 | — | — | EP | claimed |
| US-4430318-A | HAPTENS, GLOBULINS, ANTIBODIES, ERYTHROCYTES, TUMORS, ANTIGENS, METHOTREXATE, LEUCOVORIN | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1984-02-07 | — | — | US | claimed |
| EP-0096560-A1 | Assessment of nutritional status of individuals | Clayton Foundation for Research (US) | 1983-12-21 | — | — | EP | claimed |
| US-4383845-A | Foliar growth promoting mixture | RUTHERFORD JOSEPH P | 1983-05-17 | — | — | US | claimed |
| EP-0051278-A1 | Soft tertiary amine esters of bio-affecting carboxylic acids, processes for preparing and a pharmaceutical composition containing the same | MERCK & CO. INC. (US) | 1982-05-12 | — | — | EP | claimed |
| US-4148999-A | 5-FORMYL-TETRAHYDROFOLIC ACID | THE GOVERNMENT OF THE UNITED STATES OF AMERICA (US) | 1979-04-10 | — | — | US | claimed |