Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRF1 | P14222 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 7/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1750363 | 1.00 | PRF1 (0.47) | PRF1TDP1PIK3CGPIK3CAPTPN1 | |
| SCHEMBL1750860 | 0.82 | HPGDS (0.42) | PRF1HPGD | |
| SCHEMBL1751361 | 0.81 | PRF1 (0.50) | PRF1TDP1PIK3CGPIK3CAPTPN1 | |
| SCHEMBL1082139 | 0.80 | PRF1 (0.57) | PRF1TDP1PIK3CGPIK3CAPTPN1 | |
| SCHEMBL1082137 | 0.80 | PRF1 (0.57) | PRF1TDP1PIK3CGPIK3CAPTPN1 | |
| SCHEMBL12931807 | 0.80 | PRF1 (0.57) | PRF1TDP1PIK3CGPIK3CAPTPN1 | |
| SCHEMBL1751358 | 0.79 | TDP1 (0.50) | PRF1TDP1PIK3CGPIK3CAPTPN1 | |
| SCHEMBL1751360 | 0.79 | TDP1 (0.50) | PRF1TDP1PIK3CGPIK3CAPTPN1 | |
| SCHEMBL1750365 | 0.78 | PRF1 (0.47) | PRF1TDP1PIK3CGPIK3CAPTPN1 | |
| SCHEMBL1064124 | 0.76 | TDP1 (0.75) | PRF1TDP1PIK3CGPIK3CAMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022079-B2 | Methods of modulating PPAR gamma-type receptors | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2011-09-20 | — | — | US | disclosed |
| EP-1638964-B1 | NOVEL COMPOUNDS THAT MODULATE PPAR-GAMMA TYPE RECEPTORS, AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS | GALDERMA RES & DEV (FR) | 2011-07-27 | — | — | EP | disclosed |