Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TSPO | P30536 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLQ | O75417 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17504123 | 0.97 | MAPT (0.47) | MAPTGRIN2BMEN1KMT2AHDAC1 | |
| SCHEMBL18918387 | 0.89 | MEN1 (0.45) | MAPTGRIN2BMEN1KMT2AHDAC1 | |
| SCHEMBL17504125 | 0.85 | MEN1 (0.59) | MAPTMEN1KMT2AHDAC1TSHR | |
| SCHEMBL17504136 | 0.81 | KDM4E (0.41) | MAPTMEN1KMT2AHDAC1KDM4E | |
| SCHEMBL17504156 | 0.81 | GRIN2B (0.46) | MAPTGRIN2BMEN1KMT2ATSHR | |
| SCHEMBL17504153 | 0.78 | KDM4E (0.46) | MEN1KMT2ATSPOKDM4EPOLQ | |
| SCHEMBL17504167 | 0.76 | MEN1 (0.68) | MAPTMEN1KMT2ATSHRKDM4E | |
| SCHEMBL17504144 | 0.74 | TSPO (0.40) | MAPTGRIN2BMEN1KMT2ATSPO | |
| SCHEMBL17504132 | 0.66 | PGR (0.41) | MAPTMEN1KMT2ATSPOPOLQ | |
| SCHEMBL8300688 | 0.66 | MAPT (0.45) | MAPTMEN1KMT2ATSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3180319-A1 | NOVEL PYRIDAZONES AND TRIAZINONES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. Hoffmann-La Roche AG (CH) | 2017-06-21 | — | — | EP | disclosed |
| WO-2016023877-A1 | NOVEL PYRIDAZONES AND TRIAZINONES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION | F. HOFFMANN-LA ROCHE AG (CH) | 2016-02-18 | — | — | WO | disclosed |