Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 16/20 | 0.38 |
| ▸ | RAMP1 | O60894 | 5/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17525091 | 0.84 | GPR119 (0.45) | — | |
| SCHEMBL17506461 | 0.84 | CALCRL (0.39) | CALCRLRAMP1CHRM4 | |
| SCHEMBL17506465 | 0.83 | HTR2C (0.41) | NOTUMPARP1 | |
| SCHEMBL17524897 | 0.79 | CHRM3 (0.36) | CALCRLNOTUMRORCTNKS | |
| SCHEMBL17525092 | 0.79 | GFER (0.37) | NOTUMTNKSPARP1PARP2 | |
| SCHEMBL2087424 | 0.78 | CALCRL (0.55) | CALCRLRAMP1CHRM4 | |
| SCHEMBL17506421 | 0.76 | SIRT6 (0.39) | — | |
| SCHEMBL4226700 | 0.74 | CALCRL (0.44) | CALCRLRAMP1CHRM4 | |
| SCHEMBL2103739 | 0.72 | CALCRL (0.58) | CALCRLRAMP1CHRM4 | |
| SCHEMBL30231301 | 0.72 | CALCRL (0.58) | CALCRLRAMP1CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016022644-A1 | HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2016-02-11 | — | — | WO | disclosed |