Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.48 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | IL18 | Q14116 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL175596 | 0.88 | MEN1 (0.56) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL4569778 | 0.85 | MEN1 (0.53) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL174936 | 0.85 | MEN1 (0.51) | MAPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL174930 | 0.85 | RAB9A (0.52) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL175017 | 0.85 | GAA (0.56) | ALDH1A1MEN1KMT2ATSHRKDM4E | |
| SCHEMBL175419 | 0.81 | MAPT (0.54) | MAPTMEN1KMT2AHTTRAB9A | |
| SCHEMBL175262 | 0.81 | SMN1; SMN2 (0.55) | MAPTMEN1KMT2ATSHRKDM4E | |
| SCHEMBL173846 | 0.78 | STING1 (0.53) | MAPTMEN1KMT2ALMNAHTT | |
| SCHEMBL174986 | 0.78 | KMT2A (0.52) | MAPTMEN1KMT2ASAE1UBA2 | |
| Hydrochloric Acid SCHEMBL174066 | 0.77 | KMT2A (0.51) | MAPTMEN1KMT2ASAE1UBA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611806-A1 | DEUTERIUM-ENRICHED HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | Ascepion Pharmaceuticals, Inc. (CN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012028106-A1 | DEUTERIUM-ENRICHED HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS | ASCEPION PHARMACEUTICALS, INC. (CN) | 2012-03-08 | — | — | WO | disclosed |