SCHEMBL17508194

SCHEMBL17508194

Cc1ccc(Nc2ccc(C)c(N)c2)cc1N

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 6/20 0.54
ALDH1A1 P00352 4/20 0.54
CASP1 P29466 1/20 0.54
CYP3A4 P08684 6/20 0.53
THRB P10828 1/20 0.53
ALOX15 P16050 1/20 0.53
RECQL P46063 1/20 0.53
HIF1A Q16665 1/20 0.53
MAPT P10636 4/20 0.50
TSHR P16473 3/20 0.42
GAA P10253 4/20 0.42
KDM4E B2RXH2 3/20 0.42
L3MBTL1 Q9Y468 2/20 0.42
MAPK1 P28482 1/20 0.42
JAK2 O60674 1/20 0.42
RAPGEF4 Q8WZA2 2/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
G6PD P11413 1/20 0.39
NPC1 O15118 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28726059 0.91 CASP1 (0.58) TDP1ALDH1A1CASP1CYP3A4THRB
SCHEMBL11430906 0.91 TDP1 (0.58) TDP1ALDH1A1CASP1CYP3A4THRB
SCHEMBL30826546 0.89 ALDH1A1 (0.54) TDP1ALDH1A1CASP1CYP3A4THRB
SCHEMBL30826545 0.89 ALDH1A1 (0.54) TDP1ALDH1A1CASP1CYP3A4THRB
SCHEMBL9651411 0.89 ALDH1A1 (0.54) TDP1ALDH1A1CASP1CYP3A4THRB
SCHEMBL17508325 0.88 ALDH1A1 (0.53) TDP1ALDH1A1CASP1CYP3A4THRB
SCHEMBL18643912 0.88 TDP1 (0.44) TDP1ALDH1A1CASP1CYP3A4THRB
SCHEMBL24011253 0.86 RAD52 (0.57) TDP1ALDH1A1CASP1CYP3A4THRB
SCHEMBL20019377 0.86 NPSR1 (0.60) TDP1ALDH1A1CASP1CYP3A4THRB
SCHEMBL17508186 0.86 TDP1 (0.60) TDP1ALDH1A1CASP1CYP3A4THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016020112-A1 OXIDATION DYE PRECURSOR HENKEL AG & CO. KGAA (DE) 2016-02-11 WO claimed
WO-2016020112-A1 OXIDATION DYE PRECURSOR HENKEL AG & CO. KGAA (DE) 2016-02-11 WO disclosed
WO-2016020112-A1 OXIDATION DYE PRECURSOR HENKEL AG & CO. KGAA (DE) 2016-02-11 WO disclosed