SCHEMBL17508246

SCHEMBL17508246

COc1ccc(-c2ccc(C=O)cc2)c(F)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 3/20 0.57
ALDH1A1 P00352 2/20 0.56
CYP2A6 P11509 1/20 0.56
CYP2C19 P33261 2/20 0.49
APP P05067 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.44
DRD1 P21728 1/20 0.44
CYP1A2 P05177 2/20 0.43
CYP1A1 P04798 1/20 0.43
CYP1B1 Q16678 1/20 0.43
KDM4E B2RXH2 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C9 P11712 1/20 0.43
AKR1C3 P42330 2/20 0.42
AKR1C2 P52895 2/20 0.42
PTGER4 P35408 1/20 0.41
KIF11 P52732 1/20 0.41
GRM2 Q14416 1/20 0.40
TRIM24 O15164 1/20 0.40
TYR P14679 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15972467 0.87 ALDH1A1 (0.56) ERN1ALDH1A1CYP2A6SMN1; SMN2DRD1
SCHEMBL19214428 0.87 ALDH1A1 (0.55) ERN1ALDH1A1CYP2A6SMN1; SMN2CYP1A2
SCHEMBL27781767 0.84 CYP2C19 (0.58) ERN1CYP2A6CYP2C19APPSMN1; SMN2
SCHEMBL17900077 0.84 ERN1 (0.47) ERN1ALDH1A1CYP2C19APPSMN1; SMN2
SCHEMBL12740233 0.82 ERN1 (0.58) ERN1ALDH1A1CYP2A6CYP2C19SMN1; SMN2
SCHEMBL31374896 0.82 ALDH1A1 (0.58) ERN1ALDH1A1CYP2A6CYP2C19SMN1; SMN2
SCHEMBL17508271 0.82 ALDH1A1 (0.58) ERN1ALDH1A1CYP2A6CYP2C19SMN1; SMN2
SCHEMBL30979884 0.81 APP (0.51) ERN1ALDH1A1CYP2C19APPSMN1; SMN2
SCHEMBL15588476 0.81 APP (0.51) ERN1ALDH1A1CYP2C19APPSMN1; SMN2
SCHEMBL2014355 0.81 ALDH1A1 (0.56) ERN1ALDH1A1CYP2A6CYP2C19SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016019588-A1 OXACAZONE COMPOUNDS TO TREAT CLOSTRIDIUM DIFFICILE THE BROAD INSTITUTE, INC. (US) 2016-02-11 WO disclosed
WO-2016019588-A1 OXACAZONE COMPOUNDS TO TREAT CLOSTRIDIUM DIFFICILE THE BROAD INSTITUTE, INC. (US) 2016-02-11 WO disclosed