SCHEMBL17508247

SCHEMBL17508247

CN(c1ccc(C=O)cc1)c1cc(F)cc(F)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 3/20 0.53
CYP2A13 Q16696 1/20 0.53
ALDH1A1 P00352 4/20 0.46
ALDH1A3 P47895 2/20 0.46
ALDH3A1 P30838 1/20 0.46
APP P05067 2/20 0.40
MEN1 O00255 1/20 0.36
S1PR4 O95977 1/20 0.36
LMNA P02545 1/20 0.36
HSP90AA1 P07900 1/20 0.36
HPGD P15428 1/20 0.36
S1PR1 P21453 1/20 0.36
MAPK1 P28482 1/20 0.36
CCR6 P51684 1/20 0.36
KMT2A Q03164 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
TLR9 Q9NR96 1/20 0.36
TYR P14679 1/20 0.35
NTRK1 P04629 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17508235 0.84 CYP2A6 (0.48) CYP2A6CYP2A13ALDH1A1ALDH1A3ALDH3A1
SCHEMBL8189337 0.84 CYP2A6 (0.73) CYP2A6CYP2A13ALDH1A1ALDH1A3ALDH3A1
SCHEMBL17508150 0.80 CYP2A6 (0.52) CYP2A6CYP2A13ALDH1A1ALDH1A3ALDH3A1
SCHEMBL12879930 0.77 CA12 (0.38) APPNTRK1NTRK3NTRK2
SCHEMBL11843859 0.76 CYP2A6 (0.70) CYP2A6CYP2A13ALDH1A1ALDH1A3ALDH3A1
SCHEMBL95663 0.76 CYP2A6 (0.61) CYP2A6CYP2A13ALDH1A1ALDH1A3ALDH3A1
SCHEMBL17508321 0.75 CYP2A6 (0.50) CYP2A6CYP2A13ALDH1A1ALDH1A3ALDH3A1
SCHEMBL231129 0.75 HSD17B10 (0.67) CYP2A6CYP2A13ALDH1A1ALDH1A3ALDH3A1
SCHEMBL17508180 0.74 CYP2A6 (0.53) CYP2A6CYP2A13ALDH1A1ALDH1A3ALDH3A1
SCHEMBL17508237 0.74 KIF11 (0.60) CYP2A6CYP2A13ALDH1A1ALDH1A3ALDH3A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016019588-A1 OXACAZONE COMPOUNDS TO TREAT CLOSTRIDIUM DIFFICILE THE BROAD INSTITUTE, INC. (US) 2016-02-11 WO disclosed
WO-2016019588-A1 OXACAZONE COMPOUNDS TO TREAT CLOSTRIDIUM DIFFICILE THE BROAD INSTITUTE, INC. (US) 2016-02-11 WO disclosed