Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | TNF | P01375 | 2/20 | 0.42 |
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9272721 | 0.87 | TNF (0.53) | MAPTHTTLMNATNFSIRT2 | |
| SCHEMBL17508472 | 0.77 | HPGD (0.47) | MAPTKMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9858637 | 0.76 | CCNC (0.63) | MAPTHTTLMNACA12CA1 | |
| SCHEMBL17508466 | 0.75 | MAPT (0.58) | MAPTHTTLMNACA12CA1 | |
| SCHEMBL7226299 | 0.74 | SIRT2 (0.50) | MAPTHTTLMNAKMT2ATRPA1 | |
| SCHEMBL23544069 | 0.74 | TNF (0.49) | MAPTLMNATNFCACNA2D1CYP1A2 | |
| SCHEMBL1491286 | 0.74 | MAPT (0.56) | MAPTLMNATNFCACNA2D1 | |
| SCHEMBL8322359 | 0.73 | KCNA3 (0.66) | MAPTHTTLMNATNFCYP1A2 | |
| SCHEMBL9858440 | 0.73 | LMNA (0.52) | MAPTHTTLMNACA12CA1 | |
| SCHEMBL14340747 | 0.73 | KCNA3 (0.50) | MAPTHTTLMNACACNA2D1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016021742-A1 | HETEROCYCLIC COMPOUNDS AS EP4 RECEPTOR ANTAGONISTS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-02-11 | — | — | WO | disclosed |
| WO-2016021742-A1 | HETEROCYCLIC COMPOUNDS AS EP4 RECEPTOR ANTAGONISTS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-02-11 | — | — | WO | disclosed |