Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 8/20 | 0.63 |
| ▸ | CDK8 | P49336 | 8/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.44 |
| ▸ | MET | P08581 | 4/20 | 0.42 |
| ▸ | AXL | P30530 | 3/20 | 0.42 |
| ▸ | MERTK | Q12866 | 3/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9858440 | 0.88 | LMNA (0.52) | CCNCCDK8LMNAMAPTHTT | |
| SCHEMBL27303568 | 0.81 | KDR (0.49) | LMNAMAPTHTTPDGFRAKDR | |
| SCHEMBL7460943 | 0.78 | PDGFRA (0.56) | PDGFRAKDRALKMETAXL | |
| SCHEMBL20887606 | 0.77 | CCNC (1.00) | CCNCCDK8 | |
| SCHEMBL5598507 | 0.76 | CCNC (0.55) | CCNCCDK8PDGFRAKDRMET | |
| SCHEMBL17508474 | 0.76 | MAPT (0.53) | LMNAMAPTHTTCA12CA1 | |
| SCHEMBL20887646 | 0.76 | CCNC (1.00) | CCNCCDK8 | |
| SCHEMBL20887744 | 0.75 | CCNC (0.49) | CCNCCDK8LMNAPDGFRAKDR | |
| SCHEMBL20887647 | 0.74 | CCNC (1.00) | CCNCCDK8ADRA2AADRA2C | |
| SCHEMBL22434429 | 0.74 | CCNC (1.00) | CCNCCDK8ALKMETAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0410762-A1 | Naphthyridine derivatives | DowElanco (US) | 1991-01-30 | — | — | EP | disclosed |