⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12705 | 0.85 | — | — | |
| SCHEMBL13189060 | 0.85 | L3MBTL1 (0.36) | — | |
| SCHEMBL668565 | 0.84 | — | — | |
| Hydrochloric Acid SCHEMBL3710016 | 0.83 | L3MBTL1 (0.36) | — | |
| SCHEMBL20201634 | 0.79 | — | — | |
| SCHEMBL3765270 | 0.79 | — | — | |
| SCHEMBL17525383 | 0.79 | — | — | |
| SCHEMBL3034540 | 0.79 | KDM4E (0.44) | — | |
| SCHEMBL9128182 | 0.76 | L3MBTL1 (0.36) | — | |
| SCHEMBL1787237 | 0.76 | L3MBTL1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10023564-B2 | G protein-coupled receptor kinase 2 inhibitors and methods for use of the same | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2018-07-17 | — | — | US | disclosed |
| US-20170240538-A1 | G PROTEIN-COUPLED RECEPTOR KINASE 2 INHIBITORS AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN | 2017-08-24 | — | — | US | disclosed |
| WO-2016023028-A2 | G PROTEIN-COUPLED RECEPTOR KINASE 2 INHIBITORS AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-02-11 | — | — | WO | disclosed |