Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTR | Q99707 | 1/20 | 0.51 |
| ▸ | KDM5A | P29375 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.46 |
| ▸ | SCN1A | P35498 | 4/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL121297 | 0.80 | NAMPT (0.50) | MTRKDM5AMGLLSCN1ASCN5A | |
| SCHEMBL121672 | 0.80 | MTR (0.51) | MTRKDM5AKMT2ASCN1ASCN5A | |
| SCHEMBL121298 | 0.79 | MGLL (0.58) | MTRKDM5AMGLLKMT2ASCN1A | |
| SCHEMBL18216849 | 0.79 | MTR (0.59) | MTRKMT2ASCN1ASCN5ASCN9A | |
| SCHEMBL29961279 | 0.79 | MTR (0.59) | MTRKMT2ASCN1ASCN5ASCN9A | |
| SCHEMBL12076929 | 0.78 | MTR (0.48) | MTRKDM5AKMT2AALOX15SCN1A | |
| SCHEMBL12076927 | 0.78 | MTR (0.48) | MTRKDM5AKMT2AALOX15SCN1A | |
| SCHEMBL30358021 | 0.77 | KDM5A (0.50) | MTRKDM5ASCN1ASCN5ASCN9A | |
| SCHEMBL147725 | 0.76 | MGLL (0.56) | MTRKDM5AMGLLKMT2AALOX15 | |
| SCHEMBL149492 | 0.76 | MGLL (0.58) | MTRKDM5AMGLLSCN1ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611774-A1 | DI-AZETIDINYL DIAMIDE AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica, N.V. (BE) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030907-A1 | DI-AZETIDINYL DIAMIDE AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2012-03-08 | — | — | WO | disclosed |