Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 8/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | CASR | P41180 | 2/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | AGXT | P21549 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12047346 | 1.00 | TBXAS1 (0.37) | TBXAS1AOC3CASRLTA4HHDAC3 | |
| SCHEMBL12047348 | 0.90 | TBXAS1 (0.38) | TBXAS1AOC3CASRLTA4HHDAC3 | |
| SCHEMBL12047345 | 0.90 | TBXAS1 (0.38) | TBXAS1AOC3CASRLTA4HIDO1 | |
| SCHEMBL1088174 | 0.87 | TBXAS1 (0.39) | TBXAS1AOC3CASRLTA4HIDO1 | |
| SCHEMBL1088179 | 0.86 | TBXAS1 (0.38) | TBXAS1AOC3CASRLTA4HIDO1 | |
| SCHEMBL21810844 | 0.84 | TBXAS1 (0.35) | TBXAS1AOC3LTA4HHDAC3HDAC4 | |
| SCHEMBL12047351 | 0.84 | CASR (0.36) | TBXAS1CASRHDAC3HDAC4HDAC1 | |
| SCHEMBL12047349 | 0.83 | TBXAS1 (0.36) | TBXAS1AOC3LTA4HIDO1AGXT | |
| SCHEMBL1751007 | 0.83 | TBXAS1 (0.36) | TBXAS1AOC3LTA4HIDO1AGXT | |
| SCHEMBL12047352 | 0.83 | TBXAS1 (0.35) | TBXAS1AOC3HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968736-B2 | Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof | University of Pittsburgh—of the Commonwelth Systems of Higher Education (US) | 2011-06-28 | — | — | US | disclosed |
| US-20090036691-A1 | ANALOGS OF DICODERMOLIDE AND DICTYOSTATIN-1, INTERMEDIATES THEREFOR AND METHODS OF SYNTHESIS THEREOF | PITTSBURGH UNIVERSITY OF - OF THE COMMONWEALTH SYSTEM OF HIGHER | 2009-02-05 | — | — | US | disclosed |
| US-20060270862-A1 | Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof | PITTSBURGH, UNIVERSITY OF | 2006-11-30 | — | — | US | disclosed |
| US-7122686-B2 | Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof | UNIVERSITY OF PITTSBURGH (US) | 2006-10-17 | — | — | US | disclosed |
| US-20040186165-A1 | Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-09-23 | — | — | US | disclosed |
| WO-2004022552-A1 | ANALOGS OF DISCODERMOLIDE AND DICTYOSTATIN-1, INTERMEDIATES THEREFOR AND METHODS OF SYNTHESIS THEREOF | UNIVERSITY OF PITTSBURGH (US) | 2004-03-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036691-A1 | ANALOGS OF DICODERMOLIDE AND DICTYOSTATIN-1, INTERMEDIATES THEREFOR AND METHODS OF SYNTHESIS THEREOF | RRS1, RPS3A, RPS3 | TBXAS1 1252/4885AOC3 3341/4885CASR 1616/4885 |
| US-20060270862-A1 | Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof | RRS1, RPS6KA3, RPS6KA4 | TBXAS1 1173/4885AOC3 4119/4885CASR 1772/4885 |
| US-20040186165-A1 | Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof | DECR1, RRS1, WEE1 | TBXAS1 641/4885AOC3 4459/4885CASR 3345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.