Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | IDO1 | P14902 | 2/20 | 0.48 |
| ▸ | MC4R | P32245 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1521458 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2TP53IDO1MC4RALDH1A1 | |
| SCHEMBL2897780 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2TP53IDO1MC4RALDH1A1 | |
| SCHEMBL2524063 | 0.88 | SMN1; SMN2 (0.51) | SMN1; SMN2TP53IDO1MC4RALDH1A1 | |
| SCHEMBL2524061 | 0.88 | SMN1; SMN2 (0.51) | SMN1; SMN2TP53IDO1MC4RALDH1A1 | |
| SCHEMBL4783076 | 0.88 | SMN1; SMN2 (0.51) | SMN1; SMN2TP53IDO1MC4RALDH1A1 | |
| SCHEMBL5758739 | 0.87 | SMN1; SMN2 (0.50) | SMN1; SMN2TP53IDO1MC4RALDH1A1 | |
| SCHEMBL29500819 | 0.86 | CTSL (0.42) | SMN1; SMN2TP53IDO1ALDH1A1HPGD | |
| SCHEMBL1614505 | 0.83 | MC4R (0.55) | SMN1; SMN2TP53IDO1MC4RALDH1A1 | |
| SCHEMBL4288943 | 0.83 | MC4R (0.55) | SMN1; SMN2TP53IDO1MC4RALDH1A1 | |
| SCHEMBL29726536 | 0.83 | MC4R (0.55) | SMN1; SMN2TP53IDO1MC4RALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016029146-A1 | SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE | UNIVERSITY OF WASHINGTON (US) | 2016-02-25 | — | — | WO | claimed |