Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | IDO1 | P14902 | 2/20 | 0.50 |
| ▸ | MC4R | P32245 | 1/20 | 0.48 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2524063 | 1.00 | SMN1; SMN2 (0.51) | SMN1; SMN2TP53IDO1MC4RAKT3 | |
| SCHEMBL2524061 | 1.00 | SMN1; SMN2 (0.51) | SMN1; SMN2TP53IDO1MC4RAKT3 | |
| SCHEMBL5758739 | 0.89 | SMN1; SMN2 (0.50) | SMN1; SMN2TP53IDO1MC4RALDH1A1 | |
| SCHEMBL17643623 | 0.88 | AAK1 (0.44) | SMN1; SMN2TP53IDO1MC4RALDH1A1 | |
| SCHEMBL2897780 | 0.88 | SMN1; SMN2 (0.49) | SMN1; SMN2TP53IDO1MC4RALDH1A1 | |
| SCHEMBL17513301 | 0.88 | SMN1; SMN2 (0.49) | SMN1; SMN2TP53IDO1MC4RALDH1A1 | |
| SCHEMBL1521458 | 0.88 | SMN1; SMN2 (0.49) | SMN1; SMN2TP53IDO1MC4RALDH1A1 | |
| SCHEMBL25152942 | 0.86 | AAK1 (0.41) | SMN1; SMN2TP53IDO1MC4RAKT3 | |
| SCHEMBL25152836 | 0.85 | CTSL (0.41) | SMN1; SMN2TP53MC4RAAK1CTSL | |
| SCHEMBL25217019 | 0.85 | ATM (0.49) | MC4RMEN1KMT2AAAK1CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080242694-A1 | Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith | D SIDOCKY NEIL R | 2008-10-02 | — | — | US | disclosed |
| WO-2008036308-A2 | AMINO-SUBSTITUTED HETEROCYCLES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242694-A1 | Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith | JAK2, CHEK2, MTOR | SMN1; SMN2 3689/4885TP53 15/4885IDO1 419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.