Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | ESRRB | O95718 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESRRA | P11474 | 1/20 | 0.36 |
| ▸ | ESRRG | P62508 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1750829 | 0.85 | OPRD1 (0.39) | KDM4EPKMKDM1AGPR119 | |
| SCHEMBL1751805 | 0.84 | L3MBTL1 (0.45) | KDM4EABCB1TSHR | |
| SCHEMBL6535633 | 0.75 | OPRD1 (0.39) | — | |
| SCHEMBL5156499 | 0.74 | KDM1A (0.39) | KDM4EPKMKDM1AGPR119NR1H2 | |
| SCHEMBL3239831 | 0.72 | KLK7 (0.40) | — | |
| SCHEMBL10416299 | 0.72 | KLK7 (0.40) | — | |
| SCHEMBL25423853 | 0.72 | MAPK1 (0.37) | KDM4EPKMKDM1AABCB1GPR119 | |
| SCHEMBL8115429 | 0.72 | ABCB1 (0.44) | KDM4EPKMKDM1AABCB1GPR119 | |
| SCHEMBL12066125 | 0.72 | GRIN2B (0.35) | GRIN2BGRIN2C | |
| SCHEMBL8115425 | 0.72 | ABCB1 (0.44) | KDM4EPKMKDM1AABCB1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9840464-B2 | IAP binding compounds | TetraLogic Birinapant UK Ltd. (GB) | 2017-12-12 | — | — | US | disclosed |
| US-20160289183-A1 | IAP Binding Compounds | TETRALOGIC PHARMACEUTICALS CORPORATION | 2016-10-06 | — | — | US | disclosed |
| US-9394249-B2 | IAP binding compounds | TetraLogic Birinapant UK Ltd. (GB) | 2016-07-19 | — | — | US | disclosed |
| US-20150307448-A1 | IAP Binding Compounds | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2015-10-29 | — | — | US | disclosed |
| US-8802716-B2 | IAP binding compounds | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2014-08-12 | — | — | US | disclosed |
| US-20130289075-A1 | IAP BINDING COMPOUNDS | TETRALOGIC PHARMACEUTICALS CORPORATION | 2013-10-31 | — | — | US | disclosed |
| US-20110294827-A1 | IAP BINDING COMPOUNDS | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2011-12-01 | — | — | US | disclosed |
| US-7968590-B2 | IAP binding compounds | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2011-06-28 | — | — | US | disclosed |
| US-20090048183-A1 | IAP BINDING COMPOUNDS | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2009-02-19 | — | — | US | disclosed |
| US-7456209-B2 | IAP binding compounds | TETRALOGIC PHARMACEUTICALS CORPORATION (US) | 2008-11-25 | — | — | US | disclosed |
| US-20060025347-A1 | IAP binding compounds | MEDIVIR AB (SE) | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160289183-A1 | IAP Binding Compounds | BIRC5, API5, BIRC2 | KDM4E 3837/4885PKM 4295/4885KDM1A 4320/4885 |
| US-20130289075-A1 | IAP BINDING COMPOUNDS | API5, BIRC5, BIRC2 | KDM4E 3767/4885PKM 4236/4885KDM1A 4318/4885 |
| US-20150307448-A1 | IAP Binding Compounds | BIRC5, API5, BIRC2 | KDM4E 3837/4885PKM 4295/4885KDM1A 4320/4885 |
| US-20110294827-A1 | IAP BINDING COMPOUNDS | BIRC5, BIRC2, API5 | KDM4E 3718/4885PKM 4242/4885KDM1A 4145/4885 |
| US-20060025347-A1 | IAP binding compounds | BIRC5, BIRC2, API5 | KDM4E 3718/4885PKM 4242/4885KDM1A 4145/4885 |
| US-20090048183-A1 | IAP BINDING COMPOUNDS | BIRC5, BIRC2, API5 | KDM4E 3718/4885PKM 4242/4885KDM1A 4145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.