Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 2/20 | 0.67 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.42 |
| ▸ | CCR2 | P41597 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | DGAT2 | Q96PD7 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17513361 | 1.00 | GRIN2B (0.67) | GRIN2BROCK2ROCK1CCR2ALDH1A1 | |
| SCHEMBL17513374 | 0.92 | GRIN2B (0.57) | GRIN2BROCK2ROCK1CCR2ALDH1A1 | |
| SCHEMBL17513360 | 0.89 | GRIN2B (0.67) | GRIN2BROCK2ROCK1CCR2ALDH1A1 | |
| SCHEMBL17513275 | 0.87 | GRIN2B (0.55) | GRIN2BROCK2ROCK1CCR2ALDH1A1 | |
| SCHEMBL17513273 | 0.87 | GRIN2B (0.55) | GRIN2BROCK2ROCK1CCR2ALDH1A1 | |
| SCHEMBL19377910 | 0.87 | GRIN2B (0.52) | GRIN2BROCK2ROCK1CCR2ALDH1A1 | |
| SCHEMBL17513307 | 0.87 | GRIN2B (0.52) | GRIN2BROCK2ROCK1CCR2ALDH1A1 | |
| SCHEMBL17513461 | 0.85 | GRIN2B (0.53) | GRIN2BROCK2ROCK1CCR2ALDH1A1 | |
| SCHEMBL17513463 | 0.85 | GRIN2B (0.53) | GRIN2BROCK2ROCK1CCR2ALDH1A1 | |
| SCHEMBL17513363 | 0.85 | GRIN2B (0.55) | GRIN2BROCK2ROCK1CCR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016029146-A1 | SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE | UNIVERSITY OF WASHINGTON (US) | 2016-02-25 | — | — | WO | claimed |
| US-10913736-B2 | Specific inhibitors of methionyl-tRNA synthetase | UNIVERSITY OF WASHINGTON (US) | 2021-02-09 | — | — | US | disclosed |
| US-20170275279-A1 | SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE | UNIVERSITY OF WASHINGTON | 2017-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170275279-A1 | SPECIFIC INHIBITORS OF METHIONYL-TRNA SYNTHETASE | AARS1, MTR, GARS1 | GRIN2B 1938/4885ROCK2 3338/4885ROCK1 3280/4885 |
| US-10913736-B2 | Specific inhibitors of methionyl-tRNA synthetase | AARS1, MTR, GARS1 | GRIN2B 1938/4885ROCK2 3338/4885ROCK1 3280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.